Table 1

Genes differentially expressed in response to lab overexpression
Functional class
 Genes on the array (N)
 Differentially expressed transcripts (n)
 n/N × 100 (%)
 Down-regulated
 Up-regulated
Signal transduction
 107
 5
 4.7
 2
 3
Transcriptional regulation
 263
 20
 7.6
 14
 6
Cell cycle
 37
 5
 13.5
 0
 5
Cytoskeleton/structural proteins
 149
 5
 3.4
 4
 1
Metabolism
 315
 13
 4.1
 6
 7
Translation
 59
 1
 1.7
 1
 0
Heat-shock proteins
 18
 *
 *
 *
 *
Transcription/replication/repair
 73
 4
 5.5
 0
 4
Proteolytic systems/apoptosis
 62
 12
 19.4
 1
 11
Cell surface receptors/CAMs/ion channels
 181
 12
 6.6
 10
 2
Transposable elements
 35
 4
 11.4
 3
 1
Chromatin structure
 36
 4
 11.1
 2
 2
RNA binding
 59
 7
 11.9
 2
 5
Secreted proteins
 34
 2
 5.9
 2
 0
Unknown function
 85
 2
 2.4
 1
 1

ΣN = 1513
 Σn = 96
48
 48

Genes that are differentially expressed following heat-induced ubiquitous overexpression of lab in stage 10-17 hs-lab embryos, grouped according to functional classses. *The functional class 'heat-shock proteins' was excluded from the analysis (see Materials and methods). N, number of genes within a functional group present on the chip; n, number of genes differentially expressed within a functional group following lab overexpression; n/N × 100, number of differentially expressed genes within a functional class following lab overexpression, given as a percentage of the total number of genes in this class present on the array; downregulated, total number of genes within each functional class differentially downregulated following lab overexpression; upregulated, total number of genes within each functional class differentially upregulated following lab overexpression.

Leemans et al. Genome Biology 2001 2:research0015.1   doi:10.1186/gb-2001-2-5-research0015

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