Table 1 |
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|
Localization and function of selected Rab GTPases |
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| Name |
Yeast homolog |
Localization |
Expression |
Function |
|
|
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| Rab1a |
Ypt1p |
ER/cis-Golgi |
U |
ER-Golgi transport |
| Rab2a |
ER/cis-Golgi |
U |
Golgi-ER retrograde transport |
|
| Rab3a |
SV |
Neurons |
Regulation of neurotransmitter release |
|
| Rab4a |
EE |
U |
Endocytic recycling |
|
| Rab5a |
Ypt51p |
EE, CCV, PM |
U |
Budding, motility and fusion in endocytosis |
| Rab6a |
Ypt6p |
Golgi |
U |
Retrograde Golgi traffic |
| Rab7 |
Ypt7p |
LE |
U |
Late endocytic traffic |
| Rab8a |
Sec4p |
TGN, PM |
U |
TGN-PM traffic |
| Rab9a |
LE |
U |
LE-TGN traffic |
|
| Rab11a |
Ypt31p |
RE, TGN |
U |
Endocytic recycling via RE and TGN |
| Rab27a |
Melanosomes |
Melanocytes |
Movement of lytic granules and |
|
| Granules |
Platelets |
melanosomes towards PM |
||
| Lymphocytes |
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|
|
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|
See [3,4,39] for references and further details. Compartment abbreviations: CCV, clathrin-coated vesicles; EE, early endosomes; ER, endoplasmic reticulum; LE, late endosome; PM, plasma membrane; RE, recycling endosome; SV, synaptic vesicle; TGN, trans-Golgi network; U, ubiquitous. |
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|
Stenmark and Olkkonen Genome Biology 2001 2:reviews3007.1 doi:10.1186/gb-2001-2-5-reviews3007 |
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