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Highly Accessed Review

Evolution of mammalian genome organization inferred from comparative gene mapping

William J Murphy*, Roscoe Stanyon and Stephen J O'Brien

Author Affiliations

Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA

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Genome Biology 2001, 2:reviews0005-reviews0005.8  doi:10.1186/gb-2001-2-6-reviews0005

Published: 5 June 2001

Abstract

Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale, as well as into the forces that have sculpted the genomes of extant mammalian species.