Figure 2.

Domain architectures of the Lbc oncogene product, and the experimentally uncharacterized protein KIAA1415, as predicted using SMART [14,15]. The predicted domains in KIAA1415 suggest that it facilitates guanine nucleotide exchange on Rho-type small GTPases (it has Rho guanine-nucleotide exchange factor, or RhoGEF, and pleckstrin homology or PH domains), it is localized to the plasma membrane (PH domain) and it may interact with the carboxyl termini of transmembrane receptors or channels (it has PDZ domains). The generalized functions of DEP domains are not currently known. It should be noted that prediction of this protein's domain architecture does not allow prediction of either its cellular function or the phenotypic effect of its deficiency.