Table 2 |
|||
|
Linker histone variants with potential unique functions |
|||
|
Variant |
Organism |
Essential for |
Proposed function |
|
viability? |
|||
|
|
|||
|
H1A |
Xenopus |
Not known |
Specific gene repression during |
|
development |
|||
|
H1t |
Mouse |
No |
Promotion of open chromatin |
|
structure; recombination during |
|||
|
spermatogenesis |
|||
|
H10 |
Mouse |
No |
Repression of gene expression; |
|
stabilization of chromatin |
|||
|
structure during differentiation |
|||
|
H1c |
Mouse |
No |
Activation of gene expression |
|
H1S-2, |
Human |
No |
Activation of gene expression; |
|
H1S-4 |
selective depletion from active |
||
|
genes |
|||
|
|
|||
|
Brown Genome Biology 2001 2:reviews0006.1 doi:10.1186/gb-2001-2-7-reviews0006 |
|||