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Hippocampus arrays

Jonathan B Weitzman

Author Affiliations

Genome Biology 2001, 2:spotlight-20010705-01  doi:10.1186/gb-spotlight-20010705-01

The electronic version of this article is the complete one and can be found online at:


Published:5 July 2001

© 2001 BioMed Central Ltd

Research news

The hippocampus plays a role in the brain's ability to learn and remember. In the Early Edition of the Proceedings of the National Academy of Sciences, Mody et al. report the use of a microarray strategy to define genes involved in the development and function of the mouse hippocampus. They used Affymetrix oligonucleotide arrays to screen for the expression profiles of 11,000 genes in embryonic (E16) or postnatal (P1, P7, P16 and P30) mouse hippocampus tissue. They found that 1,926 genes showed dynamic changes in expression during hippocampus development. Self-organizing map (SOM) analysis defined 16 distinct gene clusters, reflecting different age-dependent expression patterns and changes in hippocampus function. For example, clusters of genes turned off at birth include a large number encoding for regulators of cell proliferation and the cell cycle. Postnatal clusters include genes involved in differentiation and synaptogenesis. These results form the basis of a neurogenomic database which will be invaluable for future studies of the development of the mammalian brain.

References

  1. Genetic enhancement of learning and memory in mice

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences

  3. [http://www.pnas.org/cgi/doi/10.1073/pnas.141244998] webcite

    Genome-wide gene expression profiles of the developing mouse hippocampus.

  4. [http://BrainGenomics.Princeton.edu] webcite

    11K Gene Clusters