Orthologs and paralogs - we need to get it right
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Correspondence: Roy A Jensen rjensen@ufl.edu
Genome Biology 2001, 2:interactions1002-interactions1002.3 doi:10.1186/gb-2001-2-8-interactions1002
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Data preparation and interannotator agreement: BioCreAtIvE Task 1B Marc E Colosimo, Alexander A Morgan, Alexander S Yeh, Jeffrey B Colombe, Lynette Hirschman BMC Bioinformatics 2005, 6(Suppl 1):S12 (24 May 2005) |
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Deposited research article
Using orthologous and paralogous proteins to identify specificity determining residues Leonid A Mirny, Mikhail S Gelfand Genome Biology 2002, 3:preprint0002-preprint0002.20 (19 February 2002) Functional specificity of proteins is assumed to be conserved among orthologs and to be different among paralogs. We used this assumption to identify the residues that determine specificity of protein-DNA and protein-ligand recognition and present a method to compute the statistical significance of the predictions. |
