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Lipocalin killer

Jonathan B Weitzman

Genome Biology 2001, 2:spotlight-20010808-01  doi:10.1186/gb-spotlight-20010808-01

The electronic version of this article is the complete one and can be found online at:


Published:8 August 2001

© 2001 BioMed Central Ltd

Research news

In the August 3 Science, Laxminarayana Devireddy and colleagues from the University of Massachusetts Medical School report the use of DNA microarrays to identify genes whose expresssion is induced during apoptosis (Science 2001, 293:829-834). They studied cell death of a mouse pro-B lymphocytic cell line upon withdrawl of interleukin-3. The gene that showed the largest induction (12.6-fold) was 24p3, which encodes a lipocalin. Lipocalins are small secreted proteins, and Devireddy et al. found that conditioned medium from dying lymphocytes induced cell death in a range of leukocytic cells. Recombinant 24p3 protein alone could also induce lymphocyte apoptosis. The cell death induced by 24p3 probably plays a role in immune-system homeostasis and in the regulation of the inflammatory response. The authors point out how important the expression profiling approach was in leading them to a unidentified killer.

References

  1. [http://www.sciencemag.org] webcite

    Science

  2. [http://www.umassmed.edu] webcite

    University of Massachusetts Medical School

  3. [http://www.jenner.ac.uk/lipocalin.htm] webcite

    The Lipocalin Website