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Highly Accessed Review

The nuclear pore complex

Stephen A Adam

Author Affiliations

Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA

Genome Biology 2001, 2:reviews0007-reviews0007.6  doi:10.1186/gb-2001-2-9-reviews0007

Published: 31 August 2001

Abstract

Nuclear pore complexes, the conduits for information exchange between the nucleus and cytoplasm, appear broadly similar in eukaryotes from yeast to human. Precisely how nuclear pore complexes regulate macromolecular and ionic traffic remains unknown, but recent advances in the identification and characterization of components of the complex by proteomics and genomics have provided new insights.