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Dendritic cell function

Jonathan B Weitzman

Author Affiliations

Genome Biology 2001, 2:spotlight-20010905-01  doi:10.1186/gb-spotlight-20010905-01


The electronic version of this article is the complete one and can be found online at:


Published:5 September 2001

© 2001 BioMed Central Ltd

Research news

Dendritic cells are antigen-presenting cells that play a critical role in linking the innate and the adaptive immune systems. In the September issue of Nature Immunology, Francesca Granucci and colleagues at the University of Milano-Bicocca, Italy, report the results of an oligonucleotide microarray screen to identify genes regulated in dendritic cells following activation by Gram-negative bacteria (Nature Immunology 2001, 2:882-888). They analysed the transcriptome of the dendritic cell-line D1 at several time points after activation with bacteria. Their analysis identified changes in a large number of genes, including genes implicated in inflammation, apoptosis, signal transduction and transcription. Also, Granucci et al. observed an induction of interleukin 2 (IL-2) mRNA at early time points (4-6 hours) and confirmed the importance of dendritic cell-derived IL-2 using bone marrow dendritic-cells from IL-2-/- knockout mice. These results provide a molecular clue to explain the priming of naive T cells by dendritic cells during the immune response.

References

  1. Dendritic cells and the control of immunity

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://immunol.nature.com] webcite

    Nature Immunology

  3. [http://www.unimib.it] webcite

    University of Milano-Bicocca

  4. [http://www.btbs.unimib.it/DCgenes] webcite

    Dendritic cell genes