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Genomic mountains

Jonathan B Weitzman

Author Affiliations

Genome Biology 2001, 2:spotlight-20010919-02  doi:10.1186/gb-spotlight-20010919-02

The electronic version of this article is the complete one and can be found online at:


Published:19 September 2001

© 2001 BioMed Central Ltd

Research news

One of the challenges for microarray analysis is making sense of the mountains of data that this technology can generate. In the September 14 Science, Stuart Kim and colleagues from Stanford University show how three-dimensional maps can be used to navigate microarray data (Science 2001, 293:2087-2092). They established a compendium of gene expression profiles for the Caenorhabditis elegans genome using data from 553 microarray experiments. They created topological maps in which distance defines correlations in gene expression profiles and the height of each mountain (43 in total) reflects clustering of gene density. The data come from microarray analysis of multiple mutant strains and different growth conditions. Each mountain contains sets of highly correlated genes, reflecting biological function (such as tissue distribution or cellular activity). Navigating this genomic terrain will provide new insights into gene function and biological processes.

References

  1. [http://www.sciencemag.org] webcite

    Science

  2. [http://www.stanford.edu] webcite

    Stanford University

  3. Genome sequence of the nematode C. elegans: a platform for investigating biology.

    PubMed Abstract | Publisher Full Text OpenURL