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Significance of two distinct types of tryptophan synthase beta chain in Bacteria, Archaea and higher plants

Gary Xie, Christian Forst, Carol Bonner and Roy A Jensen*

Genome Biology 2001, 3:research0004-research0004.13 doi:10.1186/gb-2001-3-1-research0004

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Research article   Open Access

Modelling the evolution of the archaeal tryptophan synthase

Rainer Merkl BMC Evolutionary Biology 2007, 7:59 (10 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Comparative genomics of archaea: how much have we learned in six years, and what's next?

Kira S Makarova, Eugene V Koonin Genome Biology 2003, 4:115 (16 July 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology | Editor’s summary

With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' that is prone to lineage-specific gene loss and horizontal gene exchange.

Research   Open Access

Lateral gene transfer and ancient paralogy of operons containing redundant copies of tryptophan-pathway genes in Xylella species and in heterocystous cyanobacteria

Gary Xie, Carol A Bonner, Tom Brettin, Raphael Gottardo, Nemat O Keyhani, Roy A Jensen Genome Biology 2003, 4:R14 (29 January 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Tryptophan-pathway genes that exist within an apparent operon-like organization were evaluated. A seven-gene cluster in Xylella fastidiosa exhibits a sharply delineated low-GC content. This strongly implicates lateral gene transfer. In contrast, parametric studies and protein tree phylogenies did not support the origination of a gene block in the Anabaena/Nostoc lineage by lateral gene transfer.

Research   Open Access

Dynamic diversity of the tryptophan pathway in chlamydiae: reductive evolution and a novel operon for tryptophan recapture

Gary Xie, Carol A Bonner, Roy A Jensen Genome Biology 2002, 3:research0051-research0051.17 (29 August 2002)

Abstract | Full text | PDF | PubMed | Editor’s summary

The factors that accommodate the transition of different chlamydial species to the persistent state of pathogenesis include marked differences in the strategied deplyed to obtain tryptophan from host resources. Chlamydia psittaci appears to have a novel mechanism for intercepting an early intermediate of tryptophan catabolism and recycling it back to tryptophan.

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