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Evolution of the initiating enzymes of the complement system

Masaru Nonaka* and Seita Miyazawa

Author Affiliations

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113-0033, Japan

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Genome Biology 2001, 3:reviews1001-reviews1001.5  doi:10.1186/gb-2001-3-1-reviews1001

Published: 14 December 2001

Abstract

Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway.