Figure 4.

The degree of association found among groups of genes by literature profiling correlates with their likelihood of being related. (a) The clustergram resulting from the analysis of the list of co-induced genes used to illustrate the mining technique is given for comparison. (b) A group of 50 genes was picked at random from all known human genes listed in the LocusLink database and their literature content was analyzed. (c) A group of 50 genes was picked at random from the list of known interleukins, chemokines and chemokine receptors and subjected to a similar analysis. The number of positive gene-term associations retained after filtering (term occurrence for a given gene higher than the baseline by 25%) is shown for each group. Numbers of shared terms for (a), (b) and (c), was 101, 49 and 116, respectively.