Figure 8.

Distribution of L1s with TSDs and annotated genes on chromosomes. Along each 500 kb bin along the chromosomes shown, the total number of L1s with TSDs (blue line) and the annotated genes (pink line) are indicated. Stars represent loci at which the L1 concentration is quite low and gene concentration is high. Among these loci are the histone gene cluster and MHCIII cluster on chromosome 6, a group of genes subject to X inactivation on the X chromosome, and a group of unrelated genes on chromosome 1. The corresponding cytogenetic staining pattern along the length of the chromosomes is shown below the graphs. Centromeric regions are white, and Giemsa-negative bands are indicated by the lightest gray. For the Giemsa-positive bands, the intensity of the grayscale reflects the staining intensity.