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Large-scale gene-expression studies and the challenge of multiple sclerosis

Sergio E Baranzini* and Stephen L Hauser

Author Affiliations

Department of Neurology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0435, USA

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Genome Biology 2002, 3:reviews1027-reviews1027.5  doi:10.1186/gb-2002-3-10-reviews1027

Published: 16 September 2002

Abstract

In multiple sclerosis, a complex neurodegenerative disorder, a combination of genetic and environmental factors results in inflammation and myelin damage. Recent transcription-profiling studies have found distinct gene-expression patterns in diseased tissue; such large-scale studies at different stages of the disease are contributing to understanding multiple sclerosis and developing effective therapy.