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Retina enrichment

Jonathan B Weitzman

Author Affiliations

Genome Biology 2002, 3:spotlight-20021024-01  doi:10.1186/gb-spotlight-20021024-01

The electronic version of this article is the complete one and can be found online at:


Published:24 October 2002

© 2002 BioMed Central Ltd

Research news

Many of the genes associated with human retinal diseases are preferentially expressed in the retina, and this has motivated a search for retina-specific genes. In the Early Edition of the Proceedings of the National Academy of Sciences, Katsanis et al. describe a computational approach to selecting genes that might be linked to retinopathies. They mined the human subset of the NCBI database of ESTs (dbEST) for transcripts expressed in human retinal cDNA libraries and performed an in silico subtraction to identify retina-enriched sequences. Over 900 nonredundant clusters were isolated, including many of the known retinopathy-associated genes and others that were confirmed experimentally. Katsanis et al. mapped the ESTs onto the human genome and identified several candidate genes for retinopathy disorders.

References

  1. [http://www.sph.uth.tmc.edu/RetNet] webcite

    RetNet

  2. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences

  3. [http://www.pnas.org/cgi/doi/10.1073/pnas.222409099] webcite

    A computational/functional genomics approach for the enrichment of the retinal transcriptome and the identification of positional candidate retinopathy genes

  4. [http://www.ncbi.nlm.nih.gov/dbEST/] webcite

    Expressed sequence tags database

  5. [http://hgsc.bcm.tmc.edu/retbase] webcite

    RetBase