Review
Finding signals that regulate alternative splicing in the post-genomic era
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* Corresponding author: Thomas A Cooper tcooper@bcm.tmc.edu
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Genome Biology 2002, 3:reviews0008-reviews0008.16 doi:10.1186/gb-2002-3-11-reviews0008
Published: 23 October 2002Abstract
Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting factors are required for the recognition of constitutive and alternatively spliced exons and their inclusion in pre-mRNA. Here, we discuss the regulatory elements that direct alternative splicing and how genome-wide analyses can aid in their identification.