Genome Biology

official impact factor 6.89

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Genomic functional annotation using co-evolution profiles of gene clusters

Yu Zheng, Richard J Roberts and Simon Kasif*

Genome Biology 2002, 3:research0060-research0060.9 doi:10.1186/gb-2002-3-11-research0060

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BioMed Central: 9 citations

Technical Note   Open Access

Rapid pair-wise synteny analysis of large bacterial genomes using web-based GeneOrder4.0

Padmanabhan Mahadevan, Donald Seto BMC Research Notes 2010, 3:41 (23 February 2010)

Research article   Open Access

The topology of the bacterial co-conserved protein network and its implications for predicting protein function

Anis Karimpour-Fard, Sonia M Leach, Lawrence E Hunter, Ryan T Gill BMC Genomics 2008, 9:313 (30 June 2008)

Research article   Open Access

Investigation of factors affecting prediction of protein-protein interaction networks by phylogenetic profiling

Anis Karimpour-Fard, Lawrence Hunter, Ryan T Gill BMC Genomics 2007, 8:393 (29 October 2007)

Method   Open Access Highly Accessed

Cross-species cluster co-conservation: a new method for generating protein interaction networks

Anis Karimpour-Fard, Corrella S Detweiler, Kimberly D Erickson, Lawrence Hunter, Ryan T Gill Genome Biology 2007, 8:R185 (5 September 2007)

Cluster Co-Conservation (CCC) has been extended to a method for developing protein interaction networks based on co-conservation between protein pairs across multiple species, Cross-Species Cluster Co-Conservation (CS-CCC).

Research article   Open Access Highly Accessed

Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment

Raja Jothi, Teresa M Przytycka, L Aravind BMC Bioinformatics 2007, 8:173 (23 May 2007)

Proceedings   Open Access

A Regression-based K nearest neighbor algorithm for gene function prediction from heterogeneous data

Zizhen Yao, Walter L Ruzzo BMC Bioinformatics 2006, 7(Suppl 1):S11 (20 March 2006)

Open letter   Free

Call for an enzyme genomics initiative

Peter D Karp Genome Biology 2004, 5:401 (30 July 2004)

An Enzyme Genomics Initiative is proposed, the goal of which is to obtain at least one protein sequence for each enzyme that has previously been characterized biochemically.

Research   Open Access

Detection of evolutionarily stable fragments of cellular pathways by hierarchical clustering of phyletic patterns

Galina V Glazko, Arcady R Mushegian Genome Biology 2004, 5:R32 (27 April 2004)

A hierarchy of 3,688 phyletic patterns was characterized encompassing more than 5,000 known protein-coding genes from 66 complete microbial genomes. The results indicate that gene loss and displacement has occurred in the evolution of most pathways.

Method   Open Access

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach

Michael Strong, Parag Mallick, Matteo Pellegrini, Michael J Thompson, David Eisenberg Genome Biology 2003, 4:R59 (29 August 2003)

The genome of Mycobacterium tuberculosis was used to evaluate and employ a method to infer genes likely to belong to the same operon, as judged by the nucleotide distance between genes in the same genomic orientation, and this method was combined with those of the Rosetta Stone, Phylogenetic Profile and conserved Gene Neighbor computational methods for the inference of protein function.