Genome Biology

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Finding signals that regulate alternative splicing in the post-genomic era

Andrea N Ladd and Thomas A Cooper*

Genome Biology 2002, 3:reviews0008-reviews0008.16 doi:10.1186/gb-2002-3-11-reviews0008

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BioMed Central: 12 citations

Methodology article   Open Access

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays

Katerina Kechris, Yee Yang, Ru-Fang Yeh BMC Genomics 2008, 9:551 (20 November 2008)

Research   Open Access

Identification of motifs that function in the splicing of non-canonical introns

Jill I Murray, Rodger B Voelker, Kristy L Henscheid, M Bryan Warf, J Andrew Berglund Genome Biology 2008, 9:R97 (12 June 2008)

The enrichment of specific intronic splicing enhancers upstream of weak PY tracts suggests a novel mechanism for intron recognition that compensates for a weakened canonical pre-mRNA splicing motif.

Research article   Open Access

Comparative analysis of sequence features involved in the recognition of tandem splice sites

Ralf Bortfeldt, Stefanie Schindler, Karol Szafranski, Stefan Schuster, Dirk Holste BMC Genomics 2008, 9:202 (30 April 2008)

Research article   Open Access

Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment

Mugdha Khaladkar, Jianghui Liu, Dongrong Wen, Jason TL Wang, Bin Tian BMC Genomics 2008, 9:189 (25 April 2008)

Research article   Open Access

Features generated for computational splice-site prediction correspond to functional elements

Rezarta Dogan, Lise Getoor, W John Wilbur, Stephen M Mount BMC Bioinformatics 2007, 8:410 (24 October 2007)

Research   Open Access Highly Accessed

Functional coordination of alternative splicing in the mammalian central nervous system

Matthew Fagnani, Yoseph Barash, Joanna Y Ip, Christine Misquitta, Qun Pan, Arneet L Saltzman, Ofer Shai, Leo Lee, Aviad Rozenhek, Naveed Mohammad, Sandrine Willaime-Morawek, Tomas Babak, Wen Zhang, Timothy R Hughes, Derek van der Kooy, Brendan J Frey, Benjamin J Blencowe Genome Biology 2007, 8:R108 (12 June 2007)

A microarray analysis provides new evidence suggesting that specific cellular processes in the mammalian CNS are coordinated at the level of alternative splicing, and that a complex splicing code underlies CNS-specific alternative splicing regulation.

Research article   Open Access Highly Accessed

Transcript-level annotation of Affymetrix probesets improves the interpretation of gene expression data

Hui Yu, Feng Wang, Kang Tu, Lu Xie, Yuan-Yuan Li, Yi-Xue Li BMC Bioinformatics 2007, 8:194 (11 June 2007)

Research   Open Access Highly Accessed

Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

Lars O Baumbusch, Simen Myhre, Anita Langerød, Anna Bergamaschi, Stephanie B Geisler, Per E Lønning, Wolfgang Deppert, Irene Dornreiter, Anne-Lise Børresen-Dale Molecular Cancer 2006, 5:47 (20 October 2006)

Research article   Open Access

Organization and post-transcriptional processing of focal adhesion kinase gene

Jean-Marc Corsi, Evelyne Rouer, Jean-Antoine Girault, Hervé Enslen BMC Genomics 2006, 7:198 (4 August 2006)

Research   Open Access

Phylogenetically widespread alternative splicing at unusual GYNGYN donors

Michael Hiller, Klaus Huse, Karol Szafranski, Philip Rosenstiel, Stefan Schreiber, Rolf Backofen, Matthias Platzer Genome Biology 2006, 7:R65 (25 July 2006)

Computational and experimental evidence is given for alternative splicing at the unusual GYNGYN motif in several species, enabling in most cases subtle protein variations.

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Splicing regulators: targets and drugs

Gene Yeo Genome Biology 2005, 6:240 (1 December 2005)

Recent work has revealed a complex network of distinct alternative splicing events in Drosophila as well as drugs that interfere specifically and directly with one class of splicing regulators in human cells.

Database   Open Access

XenDB: Full length cDNA prediction and cross species mapping in Xenopus laevis

Alexander Sczyrba, Michael Beckstette, Ali H Brivanlou, Robert Giegerich, Curtis R Altmann BMC Genomics 2005, 6:123 (14 September 2005)

XenDB is a database of clustered EST and cDNA sequences from Xenopus laevis; ESTs are identified by a suffix array-based clustering approach and will be useful for researchers working on comparative genome analysis.