Apollo: a sequence annotation editor

SE Lewis¹^,2 , SMJ Searle³, N Harris⁴^,2, M Gibson¹^,2, V Iyer³, J Richter⁵, C Wiel¹^,2, L Bayraktaroglu⁶, E Birney⁷, MA Crosby⁶, JS Kaminker¹^,2, BB Matthews⁶, SE Prochnik¹^,2, CD Smith¹^,2, JL Tupy¹^,2, GM Rubin¹^,2^,4^,5, S Misra¹^,2, CJ Mungall⁵ and ME Clamp³

¹Department of Molecular and Cellular Biology, Life Sciences Addition, University of California, Berkeley, CA 94720-3200, USA

²FlyBase-Berkeley, University of California, Berkeley, CA 94720-3200, USA

³Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK

⁴Genome Sciences Department, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA

⁵Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA

⁶FlyBase-Harvard, Department of Molecular and Cell Biology, Harvard University, Biological Laboratories, 16 Divinity Avenue, Cambridge, MA 02138-2020, USA

⁷European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SD, UK

author email corresponding author email

Genome Biology 2002, 3:research0082.1-0082.14doi:10.1186/gb-2002-3-12-research0082


Published:	23 December 2002

This article is part of a series of refereed research articles from Berkeley Drosophila Genome Project, FlyBase and colleagues, describing Release 3 of the Drosophila genome, which are freely available at http://genomebiology.com/drosophila/.

Subject areas: Bioinformatics, Methods, Genome studies

Abstract

The well-established inaccuracy of purely computational methods for annotating genome sequences necessitates an interactive tool to allow biological experts to refine these approximations by viewing and independently evaluating the data supporting each annotation. Apollo was developed to meet this need, enabling curators to inspect genome annotations closely and edit them. FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome and it is increasingly being used as a starting point for the development of customized annotation editing tools for other genome projects.