Table 3

Phenotypes for which QTLs have been generated using strains that have whole genome draft sequence available

Phenotype

Number of QTLs (B6xD2)

1

Alcohol drinking - preference

7

2

Alcohol drinking - acceptance

1

3

Alcohol conditioned taste aversion

3

4

Cocaine seizures

3

5

Morphine preference

1

6

Morphine analgesia

2

7

Screen test sensitivity

8

8

Ethanol-induced locomotor activity

3

9

Basal activity

1

11

Acute alcohol withdrawal

5

12

Acute pentobarbital withdrawal

3

13

Chronic alcohol withdrawal

3

14

LORR duration

4*

15

LORR Bec

14*

16

Free-choice ethanol consumption

6*

17

Behavioral effect of stress

7*

18

Porphyria

3

19

Liver injury and porphyria

3

20

Lymphocyte proportion B220 (%)

2

21

Lymphocyte proportion CD4 (%)

1^†

22

Lymphocyte proportion CD8 (%)

1

23

Hepatic lipid peroxidation potential

1

24

Peak bone mass

16*

25

Variation in TRBV4 expansion

2

26

Maximal electroshock seizure threshold

4

27

Variation in cerebellar size

4

28

Variation in IGL volume

1

29

Susceptibility to mycobacterium tuberculosis

2, 1^†

30

Acute behavioral sensitivity to paraoxon

6*

31

Circadian period of locomotor activity

1^†

32

Short-term intake of saccharin

1

33

Short-term intake of sucrose

1

34

Short-term intake of quinine

1

35

Testicular weight

1

36

Bone density

6

37

Contextual fear conditioning

5

38

Hypothermic sensitivity to quinpirole

1

39

Tolerance to quinpirole

1^†

40

Sensitivity and tolerance to quinpirole-induced hypothermia

1^†

41

Baseline locomoter activity

3^†

42

Locomotor sensitivity to quinpirole

1^†

43

Hypnotic sensitivity to ethanol

1*, 1^†

44

Body weight

1

45

Tail length

1

46

Methamphetamine responses

Chewing

5

Climbing

14

Home cage locomotor activity

20

Body temperature change

22

47

Pcp-induced behavior

3*

48

Amp-induced behavior

6*

49

Antinociceptive responsiveness to N₂O

7

50

Corticosterone response to ethanol

5

51

High-affinity choline uptake

1^†

Phenotype

Number of QTLs (B6xA/J)

52

Cocaine-induced locomotor activity

2

53

Seizure susceptibility (beta-CCM administration)

3

54

Habituated open field behavior

2, 5^†

55

Hormone-induced ovulation rate

2, 5^†

56

Light-to-dark transition behavior

3, 5^†

57

Center time behavior

5^†

58

Initial ambulation in the open field

1, 4^†

59

Vertical rearings

1, 2^†

60

Trypanosomosis resistance

1

61

Nickel-induced acute lung injury

1, 2^†

62

PKC-alpha content

1

63

PKC activity

1

Total number of QTLs

276

*QTLs identified as suggestive in the original publications. ^†QTLs identified as provisional in the original publications.

Marshall et al. Genome Biology 2002 3:research0078.1   doi:10.1186/gb-2002-3-12-research0078