Genome Biology

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Apollo: a sequence annotation editor

SE Lewis*, SMJ Searle, N Harris, M Gibson, V Iyer, J Richter, C Wiel, L Bayraktaroglu, E Birney, MA Crosby, JS Kaminker, BB Matthews, SE Prochnik, CD Smith, JL Tupy, GM Rubin, S Misra, CJ Mungall and ME Clamp

Genome Biology 2002, 3:research0082-0082.14 doi:10.1186/gb-2002-3-12-research0082

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Research article   Open Access Highly Accessed

Identification of CRISPR and riboswitch related RNAs among novel noncoding RNAs of the euryarchaeon Pyrococcus abyssi

Kounthéa Phok, Annick Moisan, Dana Rinaldi, Nicolas Brucato, Agamemnon J Carpousis, Christine Gaspin, Béatrice Clouet-d'Orval BMC Genomics 2011, 12:312 (13 June 2011)

Method   Open Access Highly Accessed

A standard variation file format for human genome sequences

Martin G Reese, Barry Moore, Colin Batchelor, Fidel Salas, Fiona Cunningham, Gabor T Marth, Lincoln Stein, Paul Flicek, Mark Yandell, Karen Eilbeck Genome Biology 2010, 11:R88 (26 August 2010)

The genome variation format (GVF) and the 10Gen dataset provide a resource for the standardization of variant files and data analysis.

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Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire

C André Lévesque, Henk Brouwer, Liliana Cano, John P Hamilton, Carson Holt, Edgar Huitema, Sylvain Raffaele, Gregg P Robideau, Marco Thines, Joe Win, Marcelo M Zerillo, Gordon W Beakes, Jeffrey L Boore, Dana Busam, Bernard Dumas, Steve Ferriera, Susan I Fuerstenberg, Claire MM Gachon, Elodie Gaulin, Francine Govers, Laura Grenville-Briggs, Neil Horner, Jessica Hostetler, Rays HY Jiang, Justin Johnson, Theerapong Krajaejun, Haining Lin, Harold JG Meijer, Barry Moore, Paul Morris et al. Genome Biology 2010, 11:R73 (13 July 2010)

The genome sequence of the plant pathogenic oomycete, Pythium ultimum and a comparison with the related potato blight pathogen genome reveals differences in pathogenicity.

Research article   Open Access

Polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status

Chris P Verschoor, Sameer D Pant, Qiumei You, Flavio S Schenkel, David F Kelton, Niel A Karrow BMC Genetics 2010, 11:23 (15 April 2010)

Research article   Open Access

Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17β-HSD type 4

Sarah E London, Yuichiro Itoh, Valentin A Lance, Petra M Wise, Preethika S Ekanayake, Randi K Oyama, Arthur P Arnold, Barney A Schlinger BMC Neuroscience 2010, 11:47 (1 April 2010)

This article is part of a collection on Zebra finch: the companion...

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Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch

Sarah E London, David F Clayton BMC Neuroscience 2010, 11:46 (1 April 2010)

This article is part of a collection on Zebra finch: the companion...

Estrogenic steroid-related genes in the zebra finch and other mammals are largely homologous, but steroidogenic enzyme genes might be less diverse in the finch and the neural expression of a cholesterol transport protein gene might be regulated by hearing song.

Research article   Open Access

Annotation and classification of the bovine T cell receptor delta genes

Carolyn TA Herzig, Marie-Paule Lefranc, Cynthia L Baldwin BMC Genomics 2010, 11:100 (9 February 2010)

Software   Open Access

The DAWGPAWS pipeline for the annotation of genes and transposable elements in plant genomes

James C Estill, Jeffrey L Bennetzen Plant Methods 2009, 5:8 (19 June 2009)

Research article   Open Access

Bos taurus genome sequence reveals the assortment of immunoglobulin and surrogate light chain genes in domestic cattle

Anna Ekman, Mikael Niku, Jenni Liljavirta, Antti Iivanainen BMC Immunology 2009, 10:22 (30 April 2009)

This article is part of a collection on Bovine: the companion...

Research article   Open Access

Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells

Carolyn TA Herzig, Cynthia L Baldwin BMC Genomics 2009, 10:191 (24 April 2009)

This article is part of a collection on Bovine: the companion...

Research article   Open Access

Characterization of the bovine type I IFN locus: rearrangements, expansions, and novel subfamilies

Angela M Walker, R Michael Roberts BMC Genomics 2009, 10:187 (24 April 2009)

This article is part of a collection on Bovine: the companion...

Research article   Open Access

Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis

Alper Uzun, Nelida Rodriguez-Osorio, Abdullah Kaya, Hongfeng Wang, John J Parrish, Valentin A Ilyin, Erdogan Memili BMC Genomics 2009, 10:183 (24 April 2009)

This article is part of a collection on Bovine: the companion...

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Genome Projector: zoomable genome map with multiple views

Kazuharu Arakawa, Satoshi Tamaki, Nobuaki Kono, Nobuhiro Kido, Keita Ikegami, Ryu Ogawa, Masaru Tomita BMC Bioinformatics 2009, 10:31 (23 January 2009)

Genome Projector provides an easy-to-use, zoomable and scrollable user interface for browsing of genomic and metabolomic data, utilizing the Google Maps interface, and currently covers 320 bacterial genomes online.

Software   Open Access

Automated paleontology of repetitive DNA with REANNOTATE

Vini Pereira BMC Genomics 2008, 9:614 (18 December 2008)

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Improved genome assembly and evidence-based global gene model set for the chordate Ciona intestinalis: new insight into intron and operon populations

Yutaka Satou, Katsuhiko Mineta, Michio Ogasawara, Yasunori Sasakura, Eiichi Shoguchi, Keisuke Ueno, Lixy Yamada, Jun Matsumoto, Jessica Wasserscheid, Ken Dewar, Graham B Wiley, Simone L Macmil, Bruce A Roe, Robert W Zeller, Kenneth EM Hastings, Patrick Lemaire, Erika Lindquist, Toshinori Endo, Kohji Hotta, Kazuo Inaba Genome Biology 2008, 9:R152 (14 October 2008)

An improved assembly of the Ciona intestinalis genome reveals that it contains non-canonical introns and that about 20% of Ciona genes reside in operons.

Software   Open Access Highly Accessed

GMODWeb: a web framework for the generic model organism database

Brian D O'Connor, Allen Day, Scott Cain, Olivier Arnaiz, Linda Sperling, Lincoln D Stein Genome Biology 2008, 9:R102 (20 June 2008)

GMODWeb is a software framework designed to speed the development of websites for model organism databases.

Software   Open Access

Discovery and assembly of repeat family pseudomolecules from sparse genomic sequence data using the Assisted Automated Assembler of Repeat Families (AAARF) algorithm

Jeremy D DeBarry, Renyi Liu, Jeffrey L Bennetzen BMC Bioinformatics 2008, 9:235 (13 May 2008)

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High-throughput bioinformatics with the Cyrille2 pipeline system

Mark WEJ Fiers, Ate van der Burgt, Erwin Datema, Joost CW de Groot, Roeland CHJ van Ham BMC Bioinformatics 2008, 9:96 (12 February 2008)

Method   Open Access Highly Accessed

Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments

Brian J Haas, Steven L Salzberg, Wei Zhu, Mihaela Pertea, Jonathan E Allen, Joshua Orvis, Owen White, C Robin Buell, Jennifer R Wortman Genome Biology 2008, 9:R7 (11 January 2008)

EVidenceModeler (EVM) is an automated annotation tool that predicts protein-coding regions, alternatively spliced transcripts and untranslated regions of eukaryotic genes.

Software   Open Access

Apollo2Go: a web service adapter for the Apollo genome viewer to enable distributed genome annotation

Kathrin Klee, Rebecca Ernst, Manuel Spannagl, Klaus FX Mayer BMC Bioinformatics 2007, 8:320 (30 August 2007)

Research   Open Access

Gene models from ESTs (GeneModelEST): an application on the Solanum lycopersicum genome

Nunzio D'Agostino, Alessandra Traini, Luigi Frusciante, Maria Chiusano BMC Bioinformatics 2007, 8(Suppl 1):S9 (8 March 2007)

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Creating a honey bee consensus gene set

Christine G Elsik, Aaron J Mackey, Justin T Reese, Natalia V Milshina, David S Roos, George M Weinstock Genome Biology 2007, 8:R13 (22 January 2007)

A high-quality consensus gene set for the honey bee (Apis mellifera) created using a new algorithm (GLEAN) is described.

Database   Open Access Highly Accessed

AgBase: a functional genomics resource for agriculture

Fiona M McCarthy, Nan Wang, G Bryce Magee, Bindu Nanduri, Mark L Lawrence, Evelyn B Camon, Daniel G Barrell, David P Hill, Mary E Dolan, W Paul Williams, Dawn S Luthe, Susan M Bridges, Shane C Burgess BMC Genomics 2006, 7:229 (8 September 2006)

Software   Open Access Highly Accessed

yrGATE: a web-based gene-structure annotation tool for the identification and dissemination of eukaryotic genes

Matthew D Wilkerson, Shannon D Schlueter, Volker Brendel Genome Biology 2006, 7:R58 (19 July 2006)

yrGATE is a new web-based tool for community gene and genome annotation.

Research article   Open Access

Complete reannotation of the Arabidopsis genome: methods, tools, protocols and the final release

Brian J Haas, Jennifer R Wortman, Catherine M Ronning, Linda I Hannick, Roger K Smith, Rama Maiti, Agnes P Chan, Chunhui Yu, Maryam Farzad, Dongying Wu, Owen White, Christopher D Town BMC Biology 2005, 3:7 (22 March 2005)

The TIGR group explain how they reannotated the Arabidopsis genome, with several thousand new genes and pseudogenes annotated, 1/3 of the original annotations refined and every protein-coding gene assigned to a Gene Ontology term.

Research article   Open Access

Molecular characterization of the singed wings locus of Drosophila melanogaster

Yuri B Schwartz, Tatiana Boykova, Elena S Belyaeva, Michael Ashburner, Igor F Zhimulev BMC Genetics 2004, 5:15 (9 June 2004)

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Impressive expressions: developing a systematic database of gene-expression patterns in Drosophila embryogenesis

Haiqiong Montalta-He, Heinrich Reichert Genome Biology 2003, 4:205 (28 January 2003)

The establishment of a database of gene-expression patterns derived from systematic highthroughput in situ hybridization studies on whole-mount Drosophila embryos vastly increases the breadth and depth that can be reached by developmental genetics.

Research   Open Access Highly Accessed

Heterochromatic sequences in a Drosophila whole-genome shotgun assembly

Roger A Hoskins, Christopher D Smith, Joseph W Carlson, A Bernardo Carvalho, Aaron Halpern, Joshua S Kaminker, Cameron Kennedy, Chris J Mungall, Beth A Sullivan, Granger G Sutton, Jiro C Yasuhara, Barbara T Wakimoto, Eugene W Myers, Susan E Celniker, Gerald M Rubin, Gary H Karpen Genome Biology 2002, 3:research0085-0085.16 (31 December 2002)

This article is part of a collection on Release 3 of the...

Annotation of an improved whole-genome shotgun assembly of the Drosophila melanogaster genome predicted 297 protein-coding genes and six non-protein-coding genes, including known heterochromatic genes, and regions of similarity to known transposable elements. Fluorescence in situ hybridization was used to correlate the genomic sequence with the cytogenetic map; the annotated euchromatic sequence extends into the centric heterochromatin on each chromosome arm.

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Annotation of the Drosophila melanogaster euchromatic genome: a systematic review

Sima Misra, Madeline A Crosby, Christopher J Mungall, Beverley B Matthews, Kathryn S Campbell, Pavel Hradecky, Yanmei Huang, Joshua S Kaminker, Gillian H Millburn, Simon E Prochnik, Christopher D Smith, Jonathan L Tupy, Eleanor J Whitfield, Leyla Bayraktaroglu, Benjamin P Berman, Brian R Bettencourt, Susan E Celniker, Aubrey DNJ de Grey, Rachel A Drysdale, Nomi L Harris, John Richter, Susan Russo, Andrew J Schroeder, ShengQiang Shu, Mark Stapleton, Chihiro Yamada, Michael Ashburner, William M Gelbart, Gerald M Rubin, Suzanna E Lewis Genome Biology 2002, 3:research0083-0083.22 (31 December 2002)

This article is part of a collection on Release 3 of the...

The recent completion of the Drosophila melanogaster genomic sequence to high quality, and the availability of a greatly expanded set of Drosophila cDNA sequences, afforded FlyBase the opportunity to significantly improve genomic annotations.

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Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome

Casey M Bergman, Barret D Pfeiffer, Diego E Rincón-Limas, Roger A Hoskins, Andreas Gnirke, Chris J Mungall, Adrienne M Wang, Brent Kronmiller, Joanne Pacleb, Soo Park, Mark Stapleton, Kenneth Wan, Reed A George, Pieter J de Jong, Juan Botas, Gerald M Rubin, Susan E Celniker Genome Biology 2002, 3:research0086-0086.20 (30 December 2002)

This article is part of a collection on Release 3 of the...

Analysis of conservation in eight genomic regions (apterous, even-skipped, fushi tarazu, twist, and Rhodopsins 1, 2, 3 and 4) from four Drosophila species (D. erecta, D. pseudoobscura, D. willistoni, and D. littoralis) covering more than 500 kb of the D. melanogaster genome. All D. melanogaster genes (and 78-82% of coding exons) identified in divergent species such as D. pseudoobscura show evidence of functional constraint. Addition of a third species can reveal functional constraint in otherwise non-significant pairwise exon comparisons.

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An integrated computational pipeline and database to support whole-genome sequence annotation

CJ Mungall, S Misra, BP Berman, J Carlson, E Frise, N Harris, B Marshall, S Shu, JS Kaminker, SE Prochnik, CD Smith, E Smith, JL Tupy, C Wiel, GM Rubin, SE Lewis Genome Biology 2002, 3:research0081-0081.11 (23 December 2002)

This article is part of a collection on Release 3 of the...

In the course of annotating the Drosophila melanogaster genome sequence, several new open-source software tools and a database schema to support large-scale genome annotation were developed and integrated in to a reusable software system for whole-genome annotation.

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Finishing a whole-genome shotgun: Release 3 of the Drosophila melanogaster euchromatic genome sequence

Susan E Celniker, David A Wheeler, Brent Kronmiller, Joseph W Carlson, Aaron Halpern, Sandeep Patel, Mark Adams, Mark Champe, Shannon P Dugan, Erwin Frise, Ann Hodgson, Reed A George, Roger A Hoskins, Todd Laverty, Donna M Muzny, Catherine R Nelson, Joanne M Pacleb, Soo Park, Barret D Pfeiffer, Stephen Richards, Erica J Sodergren, Robert Svirskas, Paul E Tabor, Kenneth Wan, Mark Stapleton, Granger G Sutton, Craig Venter, George Weinstock, Steven E Scherer, Eugene W Myers, Richard A Gibbs, Gerald M Rubin et al. Genome Biology 2002, 3:research0079-0079.14 (23 December 2002)

This article is part of a collection on Release 3 of the...

The Drosophila melanogaster genome was the first metazoan genome to be sequenced by whole-genome shotgun. Now, the sequence has been finished in a process designed to close gaps, improve sequence quality and validate the assembly.