Genome Biology

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Computational analysis of core promoters in the Drosophila genome

Uwe Ohler*, Guo-chun Liao, Heinrich Niemann and Gerald M Rubin

Genome Biology 2002, 3:research0087-0087.12 doi:10.1186/gb-2002-3-12-research0087

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BioMed Central: 28 citations

Proceedings   Open Access

GPMiner: an integrated system for mining combinatorial cis-regulatory elements in mammalian gene group

Tzong-Yi Lee, Wen-Chi Chang, Justin Hsu, Tzu-Hao Chang, Dray-Ming Shien BMC Genomics 2012, 13(Suppl 1):S3 (17 January 2012)

Proceedings   Open Access

The genomic features that affect the lengths of 5’ untranslated regions in multicellular eukaryotes

Chun-Hsi Chen, Hsuan-Yu Lin, Chia-Lin Pan, Feng-Chi Chen BMC Bioinformatics 2011, 12(Suppl 9):S3 (5 October 2011)

Research article   Open Access Highly Accessed

Functional characterization of the sciarid BhC4-1 core promoter in transgenic Drosophila

Adriana C Garcia, Daniel LG Gitaí, Fernanda C Humann, Maria L Paçó-Larson, Nadia Monesi BMC Molecular Biology 2011, 12:32 (1 August 2011)

Research article   Open Access Highly Accessed

MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters

Bastiaan JH Jansen, Iziah E Sama, Dagmar Eleveld-Trancikova, Maaike A van Hout-Kuijer, Joop H Jansen, Martijn A Huynen, Gosse J Adema BMC Genomics 2011, 12:330 (27 June 2011)

Review   Open Access

TBP-related factors: a paradigm of diversity in transcription initiation

Waseem Akhtar, Gert Jan C Veenstra Cell & Bioscience 2011, 1:23 (27 June 2011)

Research   Open Access Highly Accessed

Dynamic reprogramming of chromatin accessibility during Drosophila embryo development

Sean Thomas, Xiao-Yong Li, Peter J Sabo, Richard Sandstrom, Robert E Thurman, Theresa K Canfield, Erika Giste, William Fisher, Ann Hammonds, Susan E Celniker, Mark D Biggin, John A Stamatoyannopoulos Genome Biology 2011, 12:R43 (11 May 2011)

A map of the dynamically changing chromatin landscape throughout Drosophila development.

Research   Open Access Highly Accessed

Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome

Elizabeth A Rach, Hsiang-Yu Yuan, William H Majoros, Pavel Tomancak, Uwe Ohler Genome Biology 2009, 10:R73 (9 July 2009)

A map of transcription start sites across the Drosophila genome, providing insights into initiation patterns and spatiotemporal conditions.

Research article   Open Access Highly Accessed

TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation

Mara E Pitulescu, Martin Teichmann, Lingfei Luo, Michael Kessel BMC Biochemistry 2009, 10:16 (10 June 2009)

A novel transcriptional regulator, isoform 2 of the TATA-binding protein-like factor-interacting protein (TIPT2), binds to the cell cycle regulatory protein geminin, and together they cooperate with chromatin associated factors and the basal transcription machinery to activate transcription synergistically.

Research article   Open Access

Complex organizational structure of the genome revealed by genome-wide analysis of single and alternative promoters in Drosophila melanogaster

Qianqian Zhu, Marc S Halfon BMC Genomics 2009, 10:9 (7 January 2009)

Method   Open Access

Core promoters are predicted by their distinct physicochemical properties in the genome of Plasmodium falciparum

Kevin Brick, Junichi Watanabe, Elisabetta Pizzi Genome Biology 2008, 9:R178 (18 December 2008)

A method is presented to computationally identify core promoters in the Plasmodium falciparum genome using only DNA physicochemical properties.

Research article   Open Access

Evolution of the holozoan ribosome biogenesis regulon

Seth J Brown, Michael D Cole, Albert J Erives BMC Genomics 2008, 9:442 (24 September 2008)

Research article   Open Access

Evolutionary origin of regulatory regions of retrogenes in Drosophila

Yongsheng Bai, Claudio Casola, Esther Betrán BMC Genomics 2008, 9:241 (22 May 2008)

Research article   Open Access

Links between core promoter and basic gene features influence gene expression

Sandra Moshonov, Rofa Elfakess, Michal Golan-Mashiach, Hadar Sinvani, Rivka Dikstein BMC Genomics 2008, 9:92 (25 February 2008)

Method   Open Access Highly Accessed

Determining promoter location based on DNA structure first-principles calculations

J Ramon Goñi, Alberto Pérez, David Torrents, Modesto Orozco Genome Biology 2007, 8:R263 (11 December 2007)

A new method is presented which predicts promoter regions based on atomistic molecular dynamics simulations of small oligonucleotides, without requiring information on sequence conservation or features.

Research article   Open Access

MetaProm: a neural network based meta-predictor for alternative human promoter prediction

Junwen Wang, Lyle H Ungar, Hung Tseng, Sridhar Hannenhalli BMC Genomics 2007, 8:374 (17 October 2007)

Review   Open Access

Computational analyses of eukaryotic promoters

Michael Q Zhang BMC Bioinformatics 2007, 8(Suppl 6):S3 (27 September 2007)

Research article   Open Access

Complex regulation and multiple developmental functions of misfire, the Drosophila melanogaster ferlin gene

Michelle K Smith, Barbara T Wakimoto BMC Developmental Biology 2007, 7:21 (26 March 2007)

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Identification of plant promoter constituents by analysis of local distribution of short sequences

Yoshiharu Y Yamamoto, Hiroyuki Ichida, Minami Matsui, Junichi Obokata, Tetsuya Sakurai, Masakazu Satou, Motoaki Seki, Kazuo Shinozaki, Tomoko Abe BMC Genomics 2007, 8:67 (8 March 2007)

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Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequilibrium in eukaryote genomes using frequency distribution curves

Kenneth W Berendzen, Kurt Stüber, Klaus Harter, Dierk Wanke BMC Bioinformatics 2006, 7:522 (30 November 2006)

Review   Free

Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment

Vladimir B Bajic, Michael R Brent, Randall H Brown, Adam Frankish, Jennifer Harrow, Uwe Ohler, Victor V Solovyev, Sin Tan Genome Biology 2006, 7(Suppl 1):S3 (7 August 2006)

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Comparative genomics of Drosophila and human core promoters

Peter C FitzGerald, David Sturgill, Andrey Shyakhtenko, Brian Oliver, Charles Vinson Genome Biology 2006, 7:R53 (7 July 2006)

Comparison of DNA sequence distributions in Drosophila and human promoters suggests that different motifs have distinct functional roles.

Research article   Open Access

Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs

Victor X Jin, Gregory AC Singer, Francisco J Agosto-Pérez, Sandya Liyanarachchi, Ramana V Davuluri BMC Bioinformatics 2006, 7:114 (7 March 2006)

Research article   Open Access

Comprehensive analysis of the base composition around the transcription start site in Metazoa

Stein Aerts, Gert Thijs, Michal Dabrowski, Yves Moreau, Bart De Moor BMC Genomics 2004, 5:34 (1 June 2004)

The local base composition (GC content) varies significantly around the transcription start sites of annotated genes in several metazoan genomes, but the degree of the variation differs among animal classes.

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Prediction of Saccharomyces cerevisiae replication origins

Adam M Breier, Sourav Chatterji, Nicholas R Cozzarelli Genome Biology 2004, 5:R22 (4 March 2004)

This study presents the first algorithm, Oriscan, to predict eukaryotic replication origins and examines the structure of the origins and evolutionary conservation of origin sequences at the nucleotide level in several Saccharomyces species.

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Impressive expressions: developing a systematic database of gene-expression patterns in Drosophila embryogenesis

Haiqiong Montalta-He, Heinrich Reichert Genome Biology 2003, 4:205 (28 January 2003)

The establishment of a database of gene-expression patterns derived from systematic highthroughput in situ hybridization studies on whole-mount Drosophila embryos vastly increases the breadth and depth that can be reached by developmental genetics.

Research   Open Access Highly Accessed

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review

Sima Misra, Madeline A Crosby, Christopher J Mungall, Beverley B Matthews, Kathryn S Campbell, Pavel Hradecky, Yanmei Huang, Joshua S Kaminker, Gillian H Millburn, Simon E Prochnik, Christopher D Smith, Jonathan L Tupy, Eleanor J Whitfield, Leyla Bayraktaroglu, Benjamin P Berman, Brian R Bettencourt, Susan E Celniker, Aubrey DNJ de Grey, Rachel A Drysdale, Nomi L Harris, John Richter, Susan Russo, Andrew J Schroeder, ShengQiang Shu, Mark Stapleton, Chihiro Yamada, Michael Ashburner, William M Gelbart, Gerald M Rubin, Suzanna E Lewis Genome Biology 2002, 3:research0083-0083.22 (31 December 2002)

This article is part of a collection on Release 3 of the...

The recent completion of the Drosophila melanogaster genomic sequence to high quality, and the availability of a greatly expanded set of Drosophila cDNA sequences, afforded FlyBase the opportunity to significantly improve genomic annotations.

Software   Open Access Highly Accessed

Apollo: a sequence annotation editor

SE Lewis, SMJ Searle, N Harris, M Gibson, V Iyer, J Richter, C Wiel, L Bayraktaroglu, E Birney, MA Crosby, JS Kaminker, BB Matthews, SE Prochnik, CD Smith, JL Tupy, GM Rubin, S Misra, CJ Mungall, ME Clamp Genome Biology 2002, 3:research0082-0082.14 (23 December 2002)

This article is part of a collection on Release 3 of the...

Apollo was developed to enable curators to inspect genome annotations closely and edit them. FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome.

Software   Open Access Highly Accessed

An integrated computational pipeline and database to support whole-genome sequence annotation

CJ Mungall, S Misra, BP Berman, J Carlson, E Frise, N Harris, B Marshall, S Shu, JS Kaminker, SE Prochnik, CD Smith, E Smith, JL Tupy, C Wiel, GM Rubin, SE Lewis Genome Biology 2002, 3:research0081-0081.11 (23 December 2002)

This article is part of a collection on Release 3 of the...

In the course of annotating the Drosophila melanogaster genome sequence, several new open-source software tools and a database schema to support large-scale genome annotation were developed and integrated in to a reusable software system for whole-genome annotation.