Table 2 |
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Transitive annotation-based scale (TABS): a qualitative distance scale for the assessment of annotation reproducibility in genome projects |
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| Score |
Description |
Comment |
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| 7 |
False positive |
Original annotation predicts function without any supporting evidence |
| 6 |
Over-prediction |
Original annotation predicts a specific biochemical function without sufficient supporting
evidence |
| 5 |
Domain error |
Original annotation overlooks different domain structure of query and reference proteins |
| 4 |
False negative |
Original annotation does not provide predicted function although there is sufficient
evidence to characterize the query protein |
| 3 |
Under-prediction |
Original annotation predicts a nonspecific biochemical function although a more detailed
prediction could have been made |
| 2 |
Undefined source |
Original annotation contains undefined terms, non-homology based predictions, and
so on |
| 1 |
Typographical error |
Original annotation contains typographical errors that may be propagated in the database |
| 0 |
Total agreement |
Original annotation is correct, but annotations may be only semantically (but not
computationally) identical |
|
|
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Column names and explanations: Score, the score between two assignments; Description, a description of the potential disagreement between two projects; Comment, explanatory comments for ranking/scores. We consider scores of 0-3 as relatively benign compared to scores of 4-7, as the latter have a much more significant impact on genome sequence and database quality. |
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Ouzounis and Karp Genome Biology 2002 3:comment2001.1 doi:10.1186/gb-2002-3-2-comment2001 |
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