Genome Biology
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ReviewThe evolutionary history of effectors downstream of Cdc42 and RacSophie Cotteret and Jonathan Chernoff  Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA  author email corresponding author email
Genome Biology 2002,
3:reviews0002.1-0002.8doi:10.1186/gb-2002-3-2-reviews0002
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| Published: |
14 January 2002 |
Subject areas: Cell biology, Evolution Abstract
Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. | 
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