Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Review

The evolutionary history of effectors downstream of Cdc42 and Rac

Sophie Cotteret and Jonathan Chernoff*

Author Affiliations

Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA

For all author emails, please log on.

Genome Biology 2002, 3:reviews0002-reviews0002.8  doi:10.1186/gb-2002-3-2-reviews0002

Published: 14 January 2002

Abstract

Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.