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Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases

Susan H Harvey, Michael JE Krien and Matthew J O'Connell*

Genome Biology 2002, 3:reviews3003-reviews3003.5 doi:10.1186/gb-2002-3-2-reviews3003

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A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain

L Aravind, Lakshminarayan M Iyer, Detlef D Leipe, Eugene V Koonin Genome Biology 2004, 5:R30 (16 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

This study characterizes the KAP protein family - a newly identified sub-group of the P-loop NTPases, which have transmembrane helices inserted into the P-loop NTPase domain. Their unusual phyletic distribution suggests KAP proteins were transferred from bacteria to animals by horizontal gene transfer.

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