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Protein family review

Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases

Susan H Harvey, Michael JE Krien and Matthew J O'Connell*

Author Affiliations

Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, A'Beckett St, Melbourne, VIC 8006, Australia. Department of Genetics, University of Melbourne, Parkville, VIC 3052, Australia

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Genome Biology 2002, 3:reviews3003-reviews3003.5  doi:10.1186/gb-2002-3-2-reviews3003

Published: 30 January 2002

Abstract

The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression. Recent studies are beginning to decipher molecular details of how these processes are carried out.