Figure 1.

Structural features of the six human core SMC proteins. (a) Arrangement of domains in SMC proteins; see text for details. (b) Alignment of the residues in the amino-terminal domain of the six human SMC proteins, surrounding the 'Walker A' nucleotide-binding motif. Identical residues are shaded in yellow and conserved residues in green. Accession numbers of the sequences are listed in Table 1. (c) Alignment of the residues in the carboxy-terminal domain, surrounding the ABC signature and Walker B/DA-box motifs. Note the divergence in sequence in SMC5 and SMC6 compared to SMC1-SMC4.