Table 1 |
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|
Distribution of KilA-N, Bro-N and associated conserved domains in viral and cellular proteomes |
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| Organism |
Host, if phage or virus |
Domain architectures |
|
|
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| NCLDVs, baculoviruses |
Eukaryotes |
KilA-N solo (AMV, FPV) |
| KilA-N + Bro-C (AMV, CIV, FPV) |
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| KilA-N + T5ORF172 (CIV) |
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| KilA-N + RING finger (chordopoxviruses); ectromelia p28 [12] |
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| KilA-N + CCCH + RING finger (FPV) |
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| Bro-N solo (MSV, AMV, HzNV, LdNV, XnGV) |
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| Bro-N + Bro-N (CnBV, CpGV, PxGV) |
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| Bro-N + T5ORF172 (CIV, MSV, ESV, baculoviruses) |
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| Bro-N + Bro-C (AMV, baculoviruses); BroA, BroD of BmNV [10] |
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| Bro-N + Bro-N + Bro-C (HaNV) |
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| Bro-N + VSR nuclease (MSV, CIV) |
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| Bro-N + Bro-N (CnBV, CpGV) |
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| Bro-N + Bro-C (AMV, baculoviruses) |
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| MSV199 solo (MSV) |
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| MSV199 + T5ORF172 (AMV, MSV, CIV) |
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| MSV199 + UVRC (CIV) |
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| MSV199 + Bro-C (CIV) |
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| Bro-C solo (CIV, DpAV4, AcNV, BmNV, EpNV, LdNV, LsNV, MbNV, OpNV) |
||
| T5ORF172 solo (CIV, LdNV) |
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| Proteobacteria |
- |
KilA-N solo (N. meningitidis, X. fastidiosa) |
| Bro-N solo (N. meningitidis, X. fastidiosa, Pseudomonas aeruginosa) |
||
| Bro-N (2/3 copies) + XF1559 (X. fastidiosa) |
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| XF0704 + Bro-N (X. fastidiosa) |
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| Bro-N + P22AR-C (Escherichia coli) |
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| KilA-C solo (E. coli) |
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| φ31-ORF238N + P22AR-C (Haemophilus influenzae) |
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| φ31-ORF238N + wHTH (N. meningitidis) |
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| XF0704 solo (X. fastidiosa) |
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| XF1559 solo (X. fastidiosa) |
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| RHA solo (Pasteurella multocida) |
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| RHA + D3ORF11-C (H. influenzae) |
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| RHA + ASH (Shigella flexneri) |
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| D3ORF11-C + P22AR-N (E. coli) |
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| bIL285ORF6-N solo (E. coli) |
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| ASH solo (E. coli, S. flexneri) |
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| T5ORF172 solo (N. meningitidis) |
||
| Low-GC Gram-positive bacteria/ Firmicutes |
- |
Bro-N solo (Streptococcus pyogenes) |
| Bro-N + HTH (S. pyogenes) |
||
| Bro-N + KilA-C (S. pyogenes, Staphylococcus aureus) |
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| RHA solo (Streptococcuspneumoniae) |
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| φ31-ORF238N + KilA-C (S. pyogenes, S. aureus) |
||
| φ31-ORF238N + φSLT-orf81a (Clostridium acetobutylicum) |
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| T5ORF172 solo (Bacillus subtilis) |
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| KilA-C solo (Lactococcus lactis) |
||
| High-GC Gram-positive bacteria |
- |
Bro-N solo (Streptomyces coelicolor) |
| Phages BP7888, BP933W, BPHK97, BPN15, BPHK620, BPHK022, BPφ-R73 BPP22, BPH-19B, BPP1,
BPP4, BPP27, BPφ80, BPT5, BPVT2-Sa |
Escherichia coli |
Bro-N solo (BPN15) |
| KilA-N + KilA-C; phage P1 - KilA [14] |
||
| KilA-N + D3ORF11-C (BPHK620) |
||
| KilA-N + p63C (BP933W, BPHK97) |
||
| RHA solo (BPφ80); BPP22 ORF 201 [47] |
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| RHA + KilA-C (BPHK022, BP933W, BPP1, BPH-19B, BPHK97, BPHK620, |
||
| BPVT2-Sa); Reduced on IHF- (ROI) [48] |
||
| KilA-C solo; bacteriophage P1 antirepressor Ant1/Ant2 [49] |
||
| φ31-ORF238N + P22AR-C (BP933W, BPVT2-Sa) |
||
| D3ORF11-C + P22AR-N (BP933W, BP7888) |
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| ASH solo (BPP4, BPφ-R73, BPN15) |
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| bIL285ORF6-N + P22AR-C (BPVT2-Sa) |
||
| T5ORF172 solo (BPT5, BPP27) |
||
| Phage P22 |
Salmonella typhimurium |
P22AR-N + Bro-N + P22AR-C; BPP22 antirepressor [33,34] |
| RHA + D3ORF11-C [46] |
||
| Phage APSE-1 |
Buchnera aphidicola |
RHA (solo) |
| Bro-N (solo) |
||
| Phage D3 |
Pseudomonas aeruginosa |
KilA-N + D3ORF11-C |
| BPφPV83, BPφETA, BPφSLT |
Staphylococcus aureus |
Bro-N + KilA-C (BPφPV83) |
| φ31-ORF238N + KilA-C (BPφETA) |
||
| φSLT-ORF81a solo (BPφSLT) |
||
| RHA solo (BPφSLT) |
||
| BPbIL285, BPbIL286, BPbIL311, BPbIL309, BPpi3, BPφ31.1, BPTP901-1, BPR1T, BPBK5-T,
BPLL-H, BPTuc2009 |
Lactococcus lactis |
Bro-N + KilA-C (BPR1T, BPBK5-T, BPLL-H, BPbIL309) |
| KilA-C solo (BPR1T) |
||
| RHA solo (BpbIL310, BPbIL311) |
||
| φ31-ORF238N + bIL285ORF6-C (BPpi3, BPTuc2009, BPbIL286, BPφ31.1) |
||
| bIL285ORF6-N + bIL285ORF6-C (BPbIL285, BPTP901-1) |
||
| LcBPA2 |
Lactobacillus casei |
Bro-N solo |
| BPTP-J34, BPSfi21 |
Streptococcus thermophilus |
φ31-ORF238N + KilA-C |
| BPA118 |
Listeria monocytogenes |
φ31-ORF238N + KilA-C |
| BPSpβc2 |
Bacillus subtilis |
RHA + KilA-C |
| BPMx8 (Myxococcal phage) |
Myxococcus xanthus |
Bro-N + p63C |
|
|
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|
Iyer et al. Genome Biology 2002 3:research0012.1 doi:10.1186/gb-2002-3-3-research0012 |
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