Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
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* Corresponding author: Matthias W Hentze hentze@embl-heidelberg.de
Genome Biology 2002, 3:reviews1006-reviews1006.6 doi:10.1186/gb-2002-3-3-reviews1006
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Minireview
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife Gabriele Neu-Yilik, Niels H Gehring, Matthias W Hentze, Andreas E Kulozik Genome Biology 2004, 5:218 (30 March 2004) Two new approaches have identified physiological nonsense-mediated mRNA decay (NMD) substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression. |
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Research
Vivek Anantharaman, L Aravind Genome Biology 2003, 4:R81 (26 November 2003) Sequence profile analysis of the RelE- and ParE-type post-segregational cell killing (PSK) toxins from diverse bacteria and archaea has unified these proteins into a single superfamily. Further comparative analysis suggests that the core of the eukaryotic nonsense-mediated RNA decay system has probably evolved from a PSK-related system. |
