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Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Thomas Schell1, Andreas E Kulozik23 and Matthias W Hentze13*

Author Affiliations

1 EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany

2 Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany

3 Molecular Medicine Partnership Unit, EMBL/University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany

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Genome Biology 2002, 3:reviews1006-reviews1006.6  doi:10.1186/gb-2002-3-3-reviews1006

Published: 26 February 2002

Abstract

When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.