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MicroRNAs

Jonathan B Weitzman

Genome Biology 2002, 3:spotlight-20020328-03  doi:10.1186/gb-spotlight-20020328-03

The electronic version of this article is the complete one and can be found online at:


Published:28 March 2002

© 2002 BioMed Central Ltd

Research news

Large families of RNA molecules of 21-22 nucleotides, called microRNAs, have been found in a number of species. In an Advanced Online Publication from Nature Genetics, Eric Lai from the University of California at Berkley, describes a family of microRNAs in Drosophila (18 March 2002, DOI:10.1038/ng865). He found that 11 Drosophila microRNAs are complementary to the K-box motif (cUGUGAUa), Brd box (AGCUUUA) and GY box (uGUCUUCC) motifs present in the 3' untranslated regions (UTRs) of several basic helix-loop-helix genes (bHLH). The microRNA may bind these sequences and mediate negative post-transcriptional regulation. The conservation of some microRNAs in man and worms will prompt work on defining a regulatory role for microRNA-3'UTR RNA duplexes.

References

  1. Identification of novel genes coding for small expressed RNAs.

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://www.nature.com/ng/] webcite

    Nature Genetics

  3. [http://www.berkeley.edu] webcite

    University of California at Berkley