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Genome scans and microarrays: converging on genes for schizophrenia?

Nigel M Williams email, Michael C O'Donovan and Michael J Owen

Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK

author email corresponding author email

Genome Biology 2002, 3:reviews1011.1-1011.5doi:10.1186/gb-2002-3-4-reviews1011

Published: 27 March 2002

Subject areas: Medicine, Neurobiology, Genome studies, Genetics

Abstract

Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging on a number of key chromosomal locations. Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported.


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