Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Genome Biology 2002, 3:reviews1008-reviews1008.4 doi:10.1186/gb-2002-3-4-reviews1008Published: 13 March 2002
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.