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Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope

Eric C Schirmer and Larry Gerace*

Author Affiliations

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA

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Genome Biology 2002, 3:reviews1008-reviews1008.4 doi:10.1186/gb-2002-3-4-reviews1008

Published: 13 March 2002

Abstract

Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.