Genome Biology
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MinireviewOrganellar proteomics: the prizes and pitfalls of opening the nuclear envelopeEric C Schirmer and Larry Gerace  Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA  author email corresponding author email
Genome Biology 2002,
3:reviews1008.1-1008.4doi:10.1186/gb-2002-3-4-reviews1008
Subject areas: Cell Biology, Biochemistry and structural biology Abstract
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope. | 
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