Screening the fruitfly immune system
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA
Genome Biology 2002, 3:reviews1010-reviews1010.2 doi:10.1186/gb-2002-3-4-reviews1010Published: 27 March 2002
The anti-microbial defense system of Drosophila shows functional similarities with the vertebrate innate immune system. Two recent gene-expression profiling studies of fruitflies challenged with infectious agents have identified key molecular players in the fruitfly's response to bacterial and fungal infection, as well as a large number of immune-regulated genes with unknown immunological function.