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Genome scans and microarrays: converging on genes for schizophrenia?

Nigel M Williams*, Michael C O'Donovan and Michael J Owen

Author Affiliations

Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK

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Genome Biology 2002, 3:reviews1011-reviews1011.5 doi:10.1186/gb-2002-3-4-reviews1011

Published: 27 March 2002

Abstract

Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging on a number of key chromosomal locations. Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported.