Genome scans and microarrays: converging on genes for schizophrenia?
Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
Genome Biology 2002, 3:reviews1011-reviews1011.5 doi:10.1186/gb-2002-3-4-reviews1011Published: 27 March 2002
Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging on a number of key chromosomal locations. Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported.