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CDK7 in C. elegans

Jonathan B Weitzman

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Citation and License

Genome Biology 2002, 3:spotlight-20020418-01  doi:10.1186/gb-spotlight-20020418-01

The electronic version of this article is the complete one and can be found online at:


Published:18 April 2002

© 2002 BioMed Central Ltd

Research news

CDK7 is a kinase that is thought to play dual roles in transcription and cell-cycle regulation by phosphorylating the carboxy-terminal domain of RNA polymerase II and also phosphorylating other cyclin-dependent kinases (CDKs). In the April 16 Proceedings of the National Academy of Sciences, Wallenfang and Seydoux at the Johns Hopkins University School of Medicine describe a study of the C. elegans cdk-7 gene (Proc Natl Acad Sci USA 2002, 99:315-320). They conducted a genome-wide screen for temperature-sensitive (ts) embryonic lethal mutants affecting transcription and came up with a ts allele of cdk-7. The cdk-7ts mutants displayed defects in mRNA synthesis and RNA polymerase phosphorylation, as well as independently regulating cell-cycle progression. They also found that cdk-7 is essential in the worm for meiosis and for maintaining normal cell ploidy.

References

  1. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences

  3. [http://www.jhmi.edu] webcite

    Johns Hopkins Medical Institutions