Table 1 |
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Acetylated proteins and the corresponding acetyltransferases that act either cotranslationally (Co) or post-translationally (Post) |
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| Acetylated proteins |
Residues |
Process |
Acetyltransferases |
References |
|
|
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| Majority of eukaryotic proteins |
α-Ser, α-Ala, and so on |
Co |
NatA, NatB, and NatC |
Reviewed in [3] |
| E. coli ribosomal proteins (S18, S5, and L12) |
α-Ser, α-Ala |
Post |
RimI, RimJ, and RimL |
[4,5] |
| Regulatory peptides (β-endorphin, α-MSH, enkephalin, GHRF) |
α-Tyr, α-Ser, and α-Ala |
Post |
Unknown |
[6,17] |
| Histones (H2A, H2B, H3, H4) |
ε-Lys |
Co and Post |
GNAT group: Gcn5, PCAF, Hat1, Elp3, and Hpa2 |
Reviewed in [7,21,25] |
| MYST group: Esa1, MOF, Sas2, Sas3, Tip60, and MORF |
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| p300/CBP group |
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| Transcription factor group: TAFII250 and TFIIIC |
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| Nuclear receptors cofactors group: ACTR and SRC1 |
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| Transcription factors (p53, E2F1-3, EKLF, TFIIEβ, TFIIF, c-Jun, TCF, GATA1, MyoD,
HMGI(Y), pRb, NF-E2(MafG) and ACTR) |
ε-Lys |
Post? |
PCAF/GCN5, p300/CBP, TAFII250, SRC1?, MOZ, Tip60? and BRCA2? |
Reviewed in [8,24] |
| HMG proteins (HMG1 and HMG2) |
ε-Lys2 and ε-Lys11 |
Unknown |
p300/CBP and PCAF |
[27,28] |
| Nuclear receptor HNF-4 |
ε-Lys |
Unknown |
p300/CBP |
[32] |
| Nuclear import factors (importin-α7 and Rch1) |
ε-Lys22 |
Post |
p300/CBP |
[9] |
| α-tubulin |
ε-Lys40 |
Post |
62-67 kDa protein |
[10,41] |
|
|
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Abbreviations not mentioned in the text: BRCA2, breast cancer protein; Elp3, elongator protein, a subunit of the RNA polymerase II holoenzyme complex; Esa1, essential SAS2-related acetyltransferase; Gcn5, general control nonrepressible protein, a nucleosomal histone acetyltransferase; GHRF, growth-hormone-releasing factor; GNAT, Gcn5p-related amino-acetyltransferase superfamily; Hpa2, histone and other protein acetyltransferase; MOF, males absent on the first, an X-linked dosage-compensation protein in Drosophila; MORF, monocytic leukemia zinc-finger protein related factor; MOZ, monocytic leukemia zinc-finger protein; MYST group, named for the founding members MOZ, YBF2/SAS3 and Tip60; p53, a tumor-suppressor protein; pRb, retinoblastoma protein; Rch1, Rag1 cohort, human importin-α ; Sas2, something about silencing protein, involved in silencing at telomeres and mating-type loci; SRC1, steroid nuclear receptor coactivator; Tip60, HIV Tat-interactive protein. A question mark indicates uncertainty. |
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Polevoda and Sherman Genome Biology 2002 3:reviews0006.1 doi:10.1186/gb-2002-3-5-reviews0006 |
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