Figure 5.

Phylogenetic trees for fusion-linked COGs: α and β subunits of acetyl-CoA carboxylase. (a) β subunit (domain) (COG0777); (b) α subunit (domain) (COG0825). Protein designations are as in Figure 2. The proteins DRA0310 and PA1400, in addition to the domains corresponding to the α and β subunits of acetyl-CoA carboxylase, contain a biotin carboxylase domain and a biotin carboxyl carrier protein domain. The clustering of these proteins in phylogenetic trees almost certainly reflects HGT between the respective bacterial lineages.