Figure 3.

Relationships of ADF/cofilins with other actin-binding proteins. The ADF/cofilins are composed of a single fold (the ADF homology domain), which has sequence similarity with a domain found in drebrins, coactosin, twinfilin and Abp1p. It is not yet certain if the fold of these two domains is similar. The fold of the ADF homology domain is similar to a domain found in the gelsolin family (the 'gelsolin fold'), despite very low sequence similarity between the two.