|
Genes involved in deafness |
|
| Class of protein |
Specific proteins and genes |
|
|
|
| Myosins |
Myosin VI (MYO6), myosin VIIA (MYO7A), myosin XV (MYO15), and non-muscle myosin heavy chain gene 9 (MYH9) |
| Non-myosin cytoskeletal |
Diaphanous-1 (HDIA1), Espin (Espn) |
| Extracellular matrix |
α-tectorin (TECTA), novel protein (COCH), type XI collagen (COL11A2), and otogelin (OTOG) |
| Gap junctions/tight junctions |
Connexin 26 (GJB2), connexin 30 (GJB6), connexin 31 (GJB3), connexin 43 (GJA1), and claudin-14 (CLDN14) |
| Ion channels/transporters |
K+ channel (KCNQ4), K+ channel components (KVLQT1 and KCNE1), Na+-K+-Cl- co-transporter (Slc12a2), H+-ATPase B1 subunit (ATP6B1), pendrin (PDS, SLC26A4), and Ca2+ pump (ATP2B2) |
| Signaling molecules |
Integrin α8β1 (Itga8) |
| Transcription factors |
Pou domain transcription factors (POU4F3 and POU3F4), and Eyes absent homolog 4 (EYA4) |
| Others |
Transmembrane serine protease (TMPRSS3) and Wolfram syndrome gene 1 (WFS1) |
| Unknown function |
Otoferlin(OTOF), novel protein (DFNA5), stereocilin, harmonin, and transmembrane cochlear-expressed gene 1 (TMC1) |
|
This table does not provide a complete listing of all genes involved with deafness, but rather focuses on those involved with non-syndromic deafness in human and mouse, with a few exceptions. For a comprehensive and up-to-date listing, see [2]. | |
Parkinson and Brown Genome Biology 2002 3:comment2006.1 doi:10.1186/gb-2002-3-6-comment2006 |
|