Additional data file 1:

Multiple alignment on which Figure 1 is based

Format: RTF Size: 179KB Download file

Additional data file 2:

A list of all bHLH sequences from human

Format: RTF Size: 13KB Download file

Additional data file 3:

Multiple Alignment of the bHLH of Achaete-Scute a family proteins

Format: RTF Size: 47KB Download file

Additional data file 4:

Multiple Alignment of the bHLH of Achaete-Scute b family proteins

Format: RTF Size: 8KB Download file

Additional data file 5:

Multiple Alignment of the bHLH of AHR family proteins

Format: RTF Size: 16KB Download file

Additional data file 6:

Multiple Alignment of the bHLH of AP4 family proteins

Format: RTF Size: 7KB Download file

Additional data file 7:

Multiple Alignment of the bHLH of ARNT family proteins

Format: RTF Size: 8KB Download file

Additional data file 8:

Multiple Alignment of the bHLH of Atonal family proteins

Format: RTF Size: 18KB Download file

Additional data file 9:

Multiple Alignment of the bHLH of Beta3 and Oligo families proteins

Format: RTF Size: 17KB Download file

Additional data file 10:

Multiple Alignment of the bHLH of Bmal family proteins

Format: RTF Size: 12KB Download file

Additional data file 11:

Multiple Alignment of the bHLH of Clock family proteins

Format: RTF Size: 17KB Download file

Additional data file 12:

Multiple Alignment of the bHLH of E12/E47 family proteins

Format: RTF Size: 18KB Download file

Additional data file 13:

Multiple Alignment of the bHLH of Extramacrochaete family proteins

Format: RTF Size: 16KB Download file

:

Multiple Alignment of the bHLH of Enhancer of split family proteins

Format: RTF Size: 81KB Download file

Additional data file 15:

Multiple Alignment of the bHLH of Fig alpha family proteins

Format: RTF Size: 8KB Download file

Additional data file 16:

Multiple Alignment of the bHLH of Hairy family proteins

Format: RTF Size: 18KB Download file

Additional data file 17:

Multiple Alignment of the bHLH of Hand family proteins

Format: RTF Size: 14KB Download file

Additional data file 18:

Multiple Alignment of the bHLH of Hey family proteins

Format: RTF Size: 15KB Download file

Additional data file 19:

Multiple Alignment of the bHLH of Mad and Mnt families proteins

Format: RTF Size: 35KB Download file

Additional data file 20:

Multiple Alignment of the bHLH of Max family proteins

Format: RTF Size: 13KB Download file

Additional data file 21:

Multiple Alignment of the bHLH of Masp family proteins

Format: RTF Size: 35KB Download file

Additional data file 22:

Multiple Alignment of the bHLH of Mist family proteins

Format: RTF Size: 7KB Download file

Additional data file 23:

Multiple Alignment of the bHLH of MITF family proteins

Format: RTF Size: 11KB Download file

Additional data file 24:

Multiple Alignment of the bHLH of Myc family proteins

Format: RTF Size: 49KB Download file

Additional data file 25:

Multiple Alignment of the bHLH of Myod family proteins

Format: RTF Size: 29KB Download file

Additional data file 26:

Multiple Alignment of the bHLH of Myor family proteins

Format: RTF Size: 13KB Download file

Additional data file 27:

Multiple Alignment of the bHLH of Net family proteins

Format: RTF Size: 10KB Download file

Additional data file 28:

Multiple Alignment of the bHLH of NeuroD family proteins

Format: RTF Size: 14KB Download file

Additional data file 29:

Multiple Alignment of the bHLH of Neurogenin family proteins

Format: RTF Size: 25KB Download file

Additional data file 30:

Multiple Alignment of the bHLH of NSCL family proteins

Format: RTF Size: 8KB Download file

Additional data file 31:

Multiple Alignment of the bHLH of Paraxis family proteins

Format: RTF Size: 9KB Download file

Additional data file 32:

Multiple Alignment of the bHLH of PTF a and b families proteins

Format: RTF Size: 18KB Download file

Additional data file 33:

Multiple Alignment of the bHLH of SCL family proteins

Format: RTF Size: 13KB Download file

Additional data file 34:

Multiple Alignment of the bHLH of SRC family proteins

Format: RTF Size: 13KB Download file

Additional data file 35:

Multiple Alignment of the bHLH of SREBP family proteins

Format: RTF Size: 24KB Download file

Additional data file 36:

Multiple Alignment of the bHLH of TF4 and Mlx families proteins

Format: RTF Size: 29KB Download file

Additional data file 37:

Multiple Alignment of the bHLH of Trh, Hif, and Sim families proteins

Format: RTF Size: 51KB Download file

Additional data file 38:

Multiple Alignment of the bHLH of Twist family proteins

Format: RTF Size: 12KB Download file

Additional data file 39:

Multiple Alignment of the bHLH of USF family proteins

Format: RTF Size: 16KB Download file

Additional data file 40:

Representative phylogenetic tree of the Achaete-Scute a family of bHLH proteins

Format: JPG Size: 109KB Download file

Additional data file 41:

Representative phylogenetic tree of the Achaete-Scute b family of bHLH proteins

Format: JPG Size: 72KB Download file

Additional data file 42:

Representative phylogenetic tree of the AHR family of bHLH proteins

Format: JPG Size: 68KB Download file

Additional data file 43:

Representative phylogenetic tree of the ARNT family of bHLH proteins

Format: JPG Size: 64KB Download file

Additional data file 44:

Representative phylogenetic tree of the Atonal family of bHLH proteins

Format: JPG Size: 84KB Download file

Additional data file 45:

Representative phylogenetic tree of the Beta3, Mist, and Oligo families of bHLH proteins

Format: JPG Size: 95KB Download file

Additional data file 46:

Representative phylogenetic tree of the Bmal family of bHLH proteins

Format: JPG Size: 63KB Download file

Additional data file 47:

Representative phylogenetic tree of the Clock family of bHLH proteins

Format: JPG Size: 72KB Download file

Additional data file 48:

Representative phylogenetic tree of the E12/E47 family of bHLH proteins

Format: JPG Size: 89KB Download file

Additional data file 49:

Representative phylogenetic tree of the Extramacrochaete family of bHLH proteins

Format: JPG Size: 78KB Download file

Additional data file 50:

Representative phylogenetic tree of the Enhancer of split family of bHLH proteins

Format: JPG Size: 136KB Download file

Additional data file 51:

Representative phylogenetic tree of the Fig alpha family of bHLH proteins

Format: JPG Size: 43KB Download file

Additional data file 52:

Representative phylogenetic tree of the Hairy family of bHLH proteins

Format: JPG Size: 77KB Download file

Additional data file 53:

Representative phylogenetic tree of the Hand family of bHLH proteins

Format: JPG Size: 67KB Download file

Additional data file 54:

Representative phylogenetic tree of the Hey family of bHLH proteins

Format: JPG Size: 71KB Download file

Additional data file 55:

Representative phylogenetic tree of the Mad and Mnt families of bHLH proteins

Format: JPG Size: 84KB Download file

Additional data file 56:

Representative phylogenetic tree of the Max family of bHLH proteins

Format: JPG Size: 65KB Download file

Additional data file 57:

Representative phylogenetic tree of the Mesp family of bHLH proteins

Format: JPG Size: 85KB Download file

Additional data file 58:

Representative phylogenetic tree of the MITF family of bHLH proteins

Format: JPG Size: 72KB Download file

Additional data file 59:

Representative phylogenetic tree of the Myc family of bHLH proteins

Format: JPG Size: 102KB Download file

Additional data file 60:

Representative phylogenetic tree of the Myod family of bHLH proteins

Format: JPG Size: 119KB Download file

Additional data file 61:

Representative phylogenetic tree of the MyoR family of bHLH proteins

Format: JPG Size: 70KB Download file

Additional data file 62:

Representative phylogenetic tree of the Net family of bHLH proteins

Format: JPG Size: 56KB Download file

Additional data file 63:

Representative phylogenetic tree of the NeuroD family of bHLH proteins

Format: JPG Size: 88KB Download file

Additional data file 64:

Representative phylogenetic tree of the Neurogenin family of bHLH proteins

Format: JPG Size: 85KB Download file

Additional data file 65:

Representative phylogenetic tree of the NSCL family of bHLH proteins

Format: JPG Size: 63KB Download file

Additional data file 66:

Representative phylogenetic tree of the Paraxis family of bHLH proteins

Format: JPG Size: 40KB Download file

Additional data file 67:

Representative phylogenetic tree of the PTF a and b families of bHLH proteins

Format: JPG Size: 67KB Download file

Additional data file 68:

Representative phylogenetic tree of the SCL family of bHLH proteins

Format: JPG Size: 69KB Download file

Additional data file 69:

Representative phylogenetic tree of the SRC family of bHLH proteins

Format: JPG Size: 65KB Download file

Additional data file 70:

Representative phylogenetic tree of the SREBP family of bHLH proteins

Format: JPG Size: 75KB Download file

Additional data file 71:

Representative phylogenetic tree of the TF4 and Mlx families of bHLH proteins

Format: JPG Size: 77KB Download file

Additional data file 72:

Representative phylogenetic tree of the Trh, Hif, and Sim families of bHLH proteins

Format: JPG Size: 114KB Download file

Additional data file 73:

Representative phylogenetic tree of the Twist family of bHLH proteins

Format: JPG Size: 76KB Download file

Additional data file 74:

Representative phylogenetic tree of the USF family of bHLH proteins

Format: JPG Size: 68KB Download file