Table 1

Classification and chromosomal and subcellular localization of DUSP genes
DUSP
 Subgroup
 Human protein
 Species ortholog
 Chromosomal localization
 Subcellular localization
 References
DUSP1
 I
 hVH1/CL100
 MKP-1/3CH134 (m)
 5q35
 Nuclear
 [8,60,61,62]
DUSP2
 I
 hPAC-1
 ---
 2p11.2-2q11
 Nuclear
 [10,42,62]
DUSP4
 I
 hVH2/TYP1
 MKP-2 (r)
 8p12-p11
 Nuclear
 [42,63,64,65]
DUSP5
 I
 hVH3/B23
 Cpg21 (r)
 10q25
 Nuclear
 [48,62,66]
DUSP6
 II
 PYST1
 MKP-3/rVH6 (r)
 12q22-q23
 Cytosolic
 [49,50,51,65]
DUSP7
 II
 PYST2/B59
 MKP-X (r)
 3p21
 Cytosolic
 [49,51,65,67]
DUSP8
 III
 hVH5
 M3/6 (m)
 11p15.5
 Nuclear /cytosolic
 [13,43,44]
DUSP9
 II
 MKP-4
 ---
 Xq28
 Nuclear /cytosolic
 [45]
DUSP10
 II(?)
 MKP-5
 ---
 1q32
 Nuclear /cytosolic
 [46,52]
DUSP16
 III
 MKP-7
 MKP-M (m)
 12p12
 Cytosolic
 [14,15,36]

Compilation of DUSP genes identified in the human and other mammalian genomes. The DUSPs are classified into subgroups I, II or III (see text for details). The various alternative names for each gene in human (h) or rat (r) or mouse (m) are given. The chromosomal location of each gene and the subcellular localization of the protein product of each gene are also indicated. Multiple names are used in the literature for each member of the MAP kinase phosphatase gene family. To avoid confusion in this article, we have used the gene names recommended by the human gene nomenclature committee, which uses the root DUSP (for dual specificity phosphatase). Note that the designation of DUSP16 is provisional.

Theodosiou and Ashworth Genome Biology 2002 3:reviews3009.1   doi:10.1186/gb-2002-3-7-reviews3009