Table 1

Allele frequency differentiation of drug metabolizing enzymes on the basis of "genetic clusters" versus "racial groups," from the data of Wilson et al. [2]

Genetic clusters

Racial groups

Allele frequencies

σ₂

Allele frequencies

σ₂

Locus

C

A

B

D

African

Caucasian

East Asian

CYP1A2

0.60

0.66

0.69

0.59

0.0023

0.58

0.68

0.67

0.0030

GSTM1

0.31

0.47

0.53

0.45

0.0087

0.33

0.49

0.52

0.0104

CYP2C19

0.27

0.09

0.37

0.25

0.0134

0.22

0.08

0.354

0.0182

DIA4

0.19

0.22

0.11

0.53

0.0340

0.21

0.21

0.32

0.0040

NAT2

0.46

0.74

0.17

0.33

0.0582

0.58

0.74

0.15

0.0931

CYP2D6

0.70

0.53

0.39

0.42

0.0197

0.70

0.49

0.37

0.0279

Genetic clusters: C, primarily African; A, primarily Caucasian; B, primarily Pacific Islander; D, primarily East Asian. Racial groups: East Asian denotes Chinese plus Papua New Guinean.

Risch et al. Genome Biology 2002 3:comment2007.1-comment2007.12   doi:10.1186/gb-2002-3-7-comment2007