Table 1

Allele frequency differentiation of drug metabolizing enzymes on the basis of "genetic clusters" versus "racial groups," from the data of Wilson et al. [2]

Genetic clusters

Racial groups



Allele frequencies

σ2

Allele frequencies

σ2



Locus

C

A

B

D

African

Caucasian

East Asian


CYP1A2

0.60

0.66

0.69

0.59

0.0023

0.58

0.68

0.67

0.0030

GSTM1

0.31

0.47

0.53

0.45

0.0087

0.33

0.49

0.52

0.0104

CYP2C19

0.27

0.09

0.37

0.25

0.0134

0.22

0.08

0.354

0.0182

DIA4

0.19

0.22

0.11

0.53

0.0340

0.21

0.21

0.32

0.0040

NAT2

0.46

0.74

0.17

0.33

0.0582

0.58

0.74

0.15

0.0931

CYP2D6

0.70

0.53

0.39

0.42

0.0197

0.70

0.49

0.37

0.0279


Genetic clusters: C, primarily African; A, primarily Caucasian; B, primarily Pacific Islander; D, primarily East Asian. Racial groups: East Asian denotes Chinese plus Papua New Guinean.

Risch et al. Genome Biology 2002 3:comment2007.1-comment2007.12   doi:10.1186/gb-2002-3-7-comment2007