Genome Biology

official impact factor 6.89

Open Access

Transcriptional programs activated by exposure of human prostate cancer cells to androgen

Samuel E DePrimo, Maximilian Diehn, Joel B Nelson, Robert E Reiter, John Matese, Mike Fero, Robert Tibshirani, Patrick O Brown and James D Brooks*

Genome Biology 2002, 3:research0032-research0032.12 doi:10.1186/gb-2002-3-7-research0032

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BioMed Central: 8 citations

Method   Open Access Highly Accessed

Gene ontology analysis for RNA-seq: accounting for selection bias

Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack Genome Biology 2010, 11:R14 (4 February 2010)

GOseq is a method for GO analysis of RNA-seq data that takes into account the length bias inherent in RNA-seq

Research article   Open Access

Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells

Hongjuan Zhao, Vincent Flamand, Donna M Peehl BMC Medical Genomics 2009, 2:55 (20 August 2009)

Research article   Open Access Highly Accessed

Comparative expression pathway analysis of human and canine mammary tumors

Paolo Uva, Luigi Aurisicchio, James Watters, Andrey Loboda, Amit Kulkarni, John Castle, Fabio Palombo, Valentina Viti, Giuseppe Mesiti, Valentina Zappulli, Laura Marconato, Francesca Abramo, Gennaro Ciliberto, Armin Lahm, Nicola La Monica, Emanuele de Rinaldis BMC Genomics 2009, 10:135 (27 March 2009)

Research article   Open Access Highly Accessed

Androgen responsive intronic non-coding RNAs

Rodrigo Louro, Helder I Nakaya, Paulo P Amaral, Fernanda Festa, Mari C Sogayar, Aline M da Silva, Sergio Verjovski-Almeida, Eduardo M Reis BMC Biology 2007, 5:4 (30 January 2007)

Androgen affects the transcription levels of intronic noncoding RNAs in the same way as it affects transcription of corresponding protein-coding genes suggesting that intronic transcripts may have functional roles in human gene expression.

Research   Open Access Highly Accessed

Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors

Chad J Creighton, Kevin E Cordero, Jose M Larios, Rebecca S Miller, Michael D Johnson, Arul M Chinnaiyan, Marc E Lippman, James M Rae Genome Biology 2006, 7:R28 (7 April 2006)

Estrogen-regulated gene expression profiles of in vivo breast tumor cell lines and in vitro xenografts and breast tumors are remarkably similar.

Software   Open Access

A method for detecting and correcting feature misidentification on expression microarrays

I-Ping Tu, Marci Schaner, Maximilian Diehn, Branimir I Sikic, Patrick O Brown, David Botstein, Michael J Fero BMC Genomics 2004, 5:64 (9 September 2004)

Research   Open Access

Identification of androgen-coregulated protein networks from the microsomes of human prostate cancer cells

Michael E Wright, Jimmy Eng, James Sherman, David M Hockenbery, Peter S Nelson, Timothy Galitski, Ruedi Aebersold Genome Biology 2003, 5:R4 (23 December 2003)

A large-scale proteomic approach has been used to define cellular processes that are responsive to androgen treatment in LNCaP prostate cancer cells. The results provide evidence for the role of androgenic hormones in coordinating the expression of critical components involved in distinct cellular processes

Research   Open Access Highly Accessed

Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor

Paul-Martin Holterhus, Olaf Hiort, Janos Demeter, Patrick O Brown, James D Brooks Genome Biology 2003, 4:R37 (15 May 2003)

Most individuals with androgen insensitivity syndrome (AIS) carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations were analysed using microarrays to gain insights into the role of the AR in human genital differentiation.