Table 1

COG codes for general function and pathway/systems

Code
Genes
Description

General function

416
Information storage and processing
J
242
Translation, ribosomal structure and biogenesis
K
80
Transcription
L
94
DNA replication, recombination and repair

429
Metabolism
C
62
Energy production and conversion
G
71
Carbohydrate transport and metabolism
E
153
Amino acid transport and metabolism
F
50
Nucleotide transport and metabolism
H
54
Coenzyme metabolism
I
39
Lipid metabolism

226
Cellular processes
D
4
Cell division and chromosome partitioning
O
98
Posttranslational modification, protein turnover, chaperones
M
9
Cell envelope biogenesis, outer membrane
N
6
Cell motility and secretion
P
71
Inorganic ion transport and metabolism
T
38
Signal transduction mechanisms

127
Poorly characterized
R
119
General function prediction only
S
8
Function unknown
Pathway/system
-
613
No pathway/system assigned
C1
2
Pyruvate decarboxylation
C2
18
TCA cycle
C3
3
Glyoxylate bypass
E1
6
Arginine biosynthesis
E2
3
Phenylalanine/tyrosine biosynthesis
E3
3
Tryptophan biosynthesis
E4
2
Threonine biosynthesis
E5
1
Isoleucine biosynthesis
E7
19
Leucine biosynthesis
E8
7
Methionine biosynthesis
E9
4
Proline biosynthesis
E10
4
Histidine biosynthesis
F1
15
Purine biosynthesis
F2
3
Purine salvage
F3
12
Pyrimidine biosynthesis
F4
2
Pyrimidine salvage
F5
7
Thymidylate biosynthesis
G1
4
Glycolysis
G2
14
Gluconeogenesis
G3
6
Pentose phosphate pathway
G4
4
Entner-doudoroff pathway
H1
8
Heme biosynthesis
H3
2
FAD biosynthesis
H4
7
Biotin biosynthesis
H5
1
NAD biosynthesis
H6
7
Ubiquinone biosynthesis
H7
3
Menaquinone biosynthesis
H8
2
Thiamine biosynthesis
H9
1
Pyridoxal phosphate biosynthesis
I1
10
Fatty acid biosynthesis
J1
26
Translation factors and enzymes involved in translation
J2
30
Aminoacyl-tRNA synthetases, amino acid activation
J3
47
Ribosomal proteins - small subunit
J4
77
Ribosomal proteins - large subunit
K1
14
DNA-dependent RNA polymerase subunits
K2
7
Basal transcription factors
K3
2
Transcriptional regulators
L1
20
Basal replication machinery

The COG letter-codes for general function and pathway/system categories are given the first column (Code). The Genes column holds the number of genes in the microarray data studied that were found for each functional class. The last column (Description) gives the description for each category.

Jiménez et al. Genome Biology 2002 4:R4   doi:10.1186/gb-2002-4-1-r4