Genome Biology

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MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

Scott W Doniger, Nathan Salomonis, Kam D Dahlquist, Karen Vranizan, Steven C Lawlor and Bruce R Conklin*

Genome Biology 2003, 4:R7 doi:10.1186/gb-2003-4-1-r7

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Research article   Open Access

Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling

Chang Liu, Jianqin Li, Liangjie Wang, Fuqun Wu, Linfang Huang, Yue Xu, Jieyu Ye, Bin Xiao, Fanyi Meng, Shilin Chen, Mo Yang BMC Complementary and Alternative Medicine 2012, 12:5 (16 January 2012)

Research article   Open Access

Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera

Maria de la Paz Celorio-Mancera, Seung-Joon Ahn, Heiko Vogel, David G Heckel BMC Genomics 2011, 12:575 (23 November 2011)

Research article   Open Access

Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes

Soon-Sen Leow, Shamala Sekaran, Kalyana Sundram, YewAi Tan, Ravigadevi Sambanthamurthi BMC Genomics 2011, 12:432 (25 August 2011)

Short Report   Open Access

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1

Rajesh Ramakrishnan, Wendong Yu, Andrew P Rice BMC Research Notes 2011, 4:260 (26 July 2011)

Research article   Open Access

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate

Xinkun Wang, Xiaodong Bao, Ranu Pal, Abdulbaki Agbas, Elias K Michaelis BMC Genomics 2010, 11:360 (7 June 2010)

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Induction of neuro-protective/regenerative genes in stem cells infiltrating post-ischemic brain tissue

Gokhan Yilmaz, J Steven Alexander, Cigdem Erkuran Yilmaz, D Neil Granger Experimental & Translational Stroke Medicine 2010, 2:11 (28 May 2010)

Research   Open Access

Studies on Xenopus laevis intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult

Rachel A Heimeier, Biswajit Das, Daniel R Buchholz, Maria Fiorentino, Yun-Bo Shi Genome Biology 2010, 11:R55 (19 May 2010)

The developmental transcriptome of the Xenopus laevis intestine, from embryo to adult, reveals insights into the regulation of gut development in all vertebrates.

Research article   Open Access

Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study

Marjan J van Erk, Suzan Wopereis, Carina Rubingh, Trinette van Vliet, Elwin Verheij, Nicole HP Cnubben, Theresa L Pedersen, John W Newman, Age K Smilde, Jan Greef, Henk FJ Hendriks, Ben van Ommen BMC Medical Genomics 2010, 3:5 (23 February 2010)

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Lists2Networks: Integrated analysis of gene/protein lists

Alexander Lachmann, Avi Ma'ayan BMC Bioinformatics 2010, 11:87 (12 February 2010)

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Detecting disease associated modules and prioritizing active genes based on high throughput data

Yu-Qing Qiu, Shihua Zhang, Xiang-Sun Zhang, Luonan Chen BMC Bioinformatics 2010, 11:26 (13 January 2010)

Research article   Open Access

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1

Pavlo L Kovalenko, Zhentao Zhang, Min Cui, Steve K Clinton, James C Fleet BMC Genomics 2010, 11:26 (13 January 2010)

Research   Open Access

Use of GenMAPP and MAPPFinder to analyse pathways involved in chickens infected with the protozoan parasite Eimeria

Dennis Prickett, Michael Watson BMC Proceedings 2009, 3(Suppl 4):S7 (16 July 2009)

Research   Open Access

Methods for interpreting lists of affected genes obtained in a DNA microarray experiment

Jakob Hedegaard, Cristina Arce, Silvio Bicciato, Agnès Bonnet, Bart Buitenhuis, Melania Collado-Romero, Lene N Conley, Magali SanCristobal, Francesco Ferrari, Juan J Garrido, Martien AM Groenen, Henrik Hornshøj, Ina Hulsegge, Li Jiang, Ángeles Jiménez-Marín, Arun Kommadath, Sandrine Lagarrigue, Jack AM Leunissen, Laurence Liaubet, Pieter BT Neerincx et al. BMC Proceedings 2009, 3(Suppl 4):S5 (16 July 2009)

Research article   Open Access

A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor

Jianzhong Li, Xia Chen, Xuelian Gong, Ying Liu, Hao Feng, Lei Qiu, Zhenlin Hu, Junping Zhang BMC Genomics 2009, 10:241 (22 May 2009)

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Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion

Satish B Cheepala, Weihong Yin, Zanobia Syed, Jennifer N Gill, Alaina McMillian, Heather E Kleiner, Mark Lynch, Rasiah Loganantharaj, Marjan Trutschl, Urska Cvek, John L Clifford Molecular Cancer 2009, 8:27 (11 May 2009)

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Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress

Xinkun Wang, Asma Zaidi, Ranu Pal, Alexander S Garrett, Rogelio Braceras, Xue-wen Chen, Mary L Michaelis, Elias K Michaelis BMC Neuroscience 2009, 10:12 (19 February 2009)

Method   Open Access Highly Accessed

KEGG spider: interpretation of genomics data in the context of the global gene metabolic network

Alexey V Antonov, Sabine Dietmann, Hans W Mewes Genome Biology 2008, 9:R179 (18 December 2008)

A web-based tool for interpretation of experimentally-derived gene lists that provides global models uniting genes from different metabolic pathways.

Research article   Open Access

Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism

Sridar V Chittur, Niquiche Sangster-Guity, Paulette J McCormick BMC Genomics 2008, 9:507 (29 October 2008)

Research article   Open Access

Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis

Olga Martínez-Augustin, Manel Merlos, Antonio Zarzuelo, María Suárez, Fermín de Medina BMC Genomics 2008, 9:490 (17 October 2008)

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Presenting and exploring biological pathways with PathVisio

Martijn P van Iersel, Thomas Kelder, Alexander R Pico, Kristina Hanspers, Susan Coort, Bruce R Conklin, Chris Evelo BMC Bioinformatics 2008, 9:399 (25 September 2008)

Methodology article   Open Access Highly Accessed

Testing gene set enrichment for subset of genes: Sub-GSE

Xiting Yan, Fengzhu Sun BMC Bioinformatics 2008, 9:362 (2 September 2008)

Research article   Open Access

Altered gene expression in highly purified enterocytes from patients with active coeliac disease

Suzanne Bracken, Greg Byrne, Jacinta Kelly, John Jackson, Conleth Feighery BMC Genomics 2008, 9:377 (8 August 2008)

Research article   Open Access

Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo

Freddy J Troost, Peter van Baarlen, Patrick Lindsey, Andrea Kodde, Willem M de Vos, Michiel Kleerebezem, Robert-Jan M Brummer BMC Genomics 2008, 9:374 (5 August 2008)

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Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models

Dawei Liu, Debashis Ghosh, Xihong Lin BMC Bioinformatics 2008, 9:292 (24 June 2008)

The effect of genetic pathways on disease outcome can be estimated by combining both parametric and non-parametric modeling using kernel machines, a framework that includes nonlinear effects and interactions between genes within a single pathway.

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Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol

Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke, Agnes M Rimando BMC Medical Genomics 2008, 1:7 (20 March 2008)

Research Article   Open Access

Combining Evidence, Specificity, and Proximity towards the Normalization of Gene Ontology Terms in Text

S Gaudan, A Jimeno Yepes, V Lee, D Rebholz-Schuhmann EURASIP Journal on Bioinformatics and Systems Biology 2008, 2008:342746 (3 March 2008)

Database   Open Access

MADIBA: A web server toolkit for biological interpretation of Plasmodium and plant gene clusters

Philip J Law, Clotilde Claudel-Renard, Fourie Joubert, Abraham I Louw, Dave K Berger BMC Genomics 2008, 9:105 (28 February 2008)

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Architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks

Ana Oliveira, Kiran Patil, Jens Nielsen BMC Systems Biology 2008, 2:17 (8 February 2008)

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Gene regulatory networks in lactation: identification of global principles using bioinformatics

Danielle G Lemay, Margaret C Neville, Michael C Rudolph, Katherine S Pollard, J German BMC Systems Biology 2007, 1:56 (27 November 2007)

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Analysis of gene expression during neurite outgrowth and regeneration

Moriah L Szpara, Karen Vranizan, Yu Tai, Corey S Goodman, Terence P Speed, John Ngai BMC Neuroscience 2007, 8:100 (23 November 2007)

Research   Open Access

Molecular signatures define two main classes of meningiomas

Lucia Carvalho, Ivan Smirnov, Gilson S Baia, Zora Modrusan, Justin S Smith, Peter Jun, Joseph F Costello, Michael W McDermott, Scott R VandenBerg, Anita Lal Molecular Cancer 2007, 6:64 (15 October 2007)

Research article   Open Access

Fasting induces a biphasic adaptive metabolic response in murine small intestine

Milka Sokolović, Diederik Wehkamp, Aleksandar Sokolović, Jacqueline Vermeulen, Lisa A Gilhuijs-Pederson, Rachel IM van Haaften, Yuri Nikolsky, Chris TA Evelo, Antoine HC van Kampen, Theodorus BM Hakvoort, Wouter H Lamers BMC Genomics 2007, 8:361 (9 October 2007)

Methodology article   Open Access

Linking microarray reporters with protein functions

Stan Gaj, Arie van Erk, Rachel IM van Haaften, Chris TA Evelo BMC Bioinformatics 2007, 8:360 (26 September 2007)

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An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells

Soma Mandal, James R Davie BMC Cancer 2007, 7:181 (20 September 2007)

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The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Da Huang, Brad T Sherman, Qina Tan, Jack R Collins, W Gregory Alvord, Jean Roayaei, Robert Stephens, Michael W Baseler, H Clifford Lane, Richard A Lempicki Genome Biology 2007, 8:R183 (4 September 2007)

The DAVID gene functional classification tool uses a novel fuzzy clustering algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules.

Methodology article   Open Access

Post hoc pattern matching: assigning significance to statistically defined expression patterns in single channel microarray data

Randall Hulshizer, Eric M Blalock BMC Bioinformatics 2007, 8:240 (5 July 2007)

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Genome Expression Pathway Analysis Tool – Analysis and visualization of microarray gene expression data under genomic, proteomic and metabolic context

Markus Weniger, Julia C Engelmann, Jörg Schultz BMC Bioinformatics 2007, 8:179 (2 June 2007)

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Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation of Escherichia coli

Gunnar Schramm, Marc Zapatka, Roland Eils, Rainer König BMC Bioinformatics 2007, 8:149 (8 May 2007)

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Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis

Carsten W Lederer, Antonietta Torrisi, Maria Pantelidou, Niovi Santama, Sebastiano Cavallaro BMC Genomics 2007, 8:26 (23 January 2007)

Identification of genes misregulated in the motor cortex of people with amyotrophic lateral sclerosis (ALS) has uncovered novel aspects of ALS pathology and points to using existing medication to rapidly develop new symptomatic therapies.

Review   Open Access Highly Accessed

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Lyn-Marie Birkholtz, Olivier Bastien, Gordon Wells, Delphine Grando, Fourie Joubert, Vinod Kasam, Marc Zimmermann, Philippe Ortet, Nicolas Jacq, Nadia Saïdani, Sylvaine Roy, Martin Hofmann-Apitius, Vincent Breton, Abraham I Louw, Eric Maréchal Malaria Journal 2006, 5:110 (17 November 2006)

A review of the different tools and strategies that have recently been developed to process the huge amount of data produced by the X-omic projects. This includes the comparison of protein sequences, high throughput reconstruction of molecular phylogenies, representation of biological processes, methods to integrate X-omic generated data following drug treatments and in silico prediction of protein structure and identification of specific ligand.

Research   Open Access Highly Accessed

Pathway and gene-set activation measurement from mRNA expression data: the tissue distribution of human pathways

David M Levine, David R Haynor, John C Castle, Sergey B Stepaniants, Matteo Pellegrini, Mao Mao, Jason M Johnson Genome Biology 2006, 7:R93 (17 October 2006)

A comparison of five different measures of pathway expression and a public map of pathway expression in human tissues are presented.

Research   Open Access

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells

Tzu-Ling Sung, Andrew P Rice Retrovirology 2006, 3:66 (2 October 2006)

Methodology article   Open Access Highly Accessed

Combining evidence, biomedical literature and statistical dependence: new insights for functional annotation of gene sets

Marc Aubry, Annabelle Monnier, Celine Chicault, Marie de Tayrac, Marie-Dominique Galibert, Anita Burgun, Jean Mosser BMC Bioinformatics 2006, 7:241 (4 May 2006)

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Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation

Jamie A Lee, Robert S Sinkovits, Dennis Mock, Eva L Rab, Jennifer Cai, Peng Yang, Brian Saunders, Robert C Hsueh, Sangdun Choi, Shankar Subramaniam, Richard H Scheuermann, BMC Bioinformatics 2006, 7:237 (2 May 2006)

Research article   Open Access

Biologically relevant effects of mRNA amplification on gene expression profiles

Rachel IM van Haaften, Blanche Schroen, Ben JA Janssen, Arie van Erk, Jacques JM Debets, Hubert JM Smeets, Jos FM Smits, Arthur van den Wijngaard, Yigal M Pinto, Chris TA Evelo BMC Bioinformatics 2006, 7:200 (11 April 2006)

Methodology   Open Access

A flexible representation of omic knowledge for thorough analysis of microarray data

Yoshikazu Hasegawa, Motoaki Seki, Yoshiki Mochizuki, Naohiko Heida, Katsura Hirosawa, Naoki Okamoto, Tetsuya Sakurai, Masakazu Satou, Kenji Akiyama, Kei Iida, Kisik Lee, Shigehiko Kanaya, Taku Demura, Kazuo Shinozaki, Akihiko Konagaya, Tetsuro Toyoda Plant Methods 2006, 2:5 (2 March 2006)

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GO-Diff: Mining functional differentiation between EST-based transcriptomes

Zuozhou Chen, Weilin Wang, Xuefeng Ling, Jane Liu, Liangbiao Chen BMC Bioinformatics 2006, 7:72 (16 February 2006)

Methodology article   Open Access Highly Accessed

Finding biological process modifications in cancer tissues by mining gene expression correlations

Giacomo Gamberoni, Sergio Storari, Stefano Volinia BMC Bioinformatics 2006, 7:6 (9 January 2006)

Research   Open Access Highly Accessed

Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

Rong Mao, Xiaowen Wang, Edward L Spitznagel, Laurence P Frelin, Jason C Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J Downey, Jonathan Pevsner Genome Biology 2005, 6:R107 (16 December 2005)

Microarray analysis of transcript levels in fetal cerebellum and heart tissues of Down syndrome patients showed a disruption only of chromosome 21 gene expression.

Methodology article   Open Access Highly Accessed

Pathway level analysis of gene expression using singular value decomposition

John Tomfohr, Jun Lu, Thomas B Kepler BMC Bioinformatics 2005, 6:225 (12 September 2005)

Methodology article   Open Access

Automation of gene assignments to metabolic pathways using high-throughput expression data

Liviu Popescu, Golan Yona BMC Bioinformatics 2005, 6:217 (31 August 2005)

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L2L: a simple tool for discovering the hidden significance in microarray expression data

John C Newman, Alan M Weiner Genome Biology 2005, 6:R81 (31 August 2005)

A database with lists of differentially expressed genes from published microarray studies is presented together with an application for mining the database with the user’s own microarray data, allowing the identification of novel biological patterns in microarray data.

Research article   Open Access

Dynamic covariation between gene expression and proteome characteristics

Mansour Sharabiani, Markku Siermala, Tommi O Lehtinen, Mauno Vihinen BMC Bioinformatics 2005, 6:215 (30 August 2005)

Software   Open Access

DynGO: a tool for visualizing and mining of Gene Ontology and its associations

Hongfang Liu, Zhang-Zhi Hu, Cathy H Wu BMC Bioinformatics 2005, 6:201 (9 August 2005)

Methodology article   Open Access Highly Accessed

PAGE: Parametric Analysis of Gene Set Enrichment

Seon-Young Kim, David J Volsky BMC Bioinformatics 2005, 6:144 (8 June 2005)

Research article   Open Access

Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

Pascale Anderle, Thierry Sengstag, David M Mutch, Martin Rumbo, Viviane Praz, Robert Mansourian, Mauro Delorenzi, Gary Williamson, Matthew-Alan Roberts BMC Genomics 2005, 6:69 (10 May 2005)

Methodology article   Open Access

In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip® technology

Dmitry N Grigoryev, Shwu-Fan Ma, Brett A Simon, Rafael A Irizarry, Shui Q Ye, Joe GN Garcia BMC Genomics 2005, 6:62 (4 May 2005)

Research   Open Access

Identifying genetic networks underlying myometrial transition to labor

Nathan Salomonis, Nathalie Cotte, Alexander C Zambon, Katherine S Pollard, Karen Vranizan, Scott W Doniger, Gregory Dolganov, Bruce R Conklin Genome Biology 2005, 6:R12 (28 January 2005)

A time course of gene expression at the onset of labor reveals transcriptional networks associated with activation of the uterine muscle and identifies targets for drugs to prevent premature labor.

Research article   Open Access

Gene expression in the brain and kidney of rainbow trout in response to handling stress

Aleksei Krasnov, Heikki Koskinen, Petri Pehkonen, Caird E Rexroad, Sergey Afanasyev, Hannu Mölsä BMC Genomics 2005, 6:3 (6 January 2005)

Methodology article   Open Access

Comparing functional annotation analyses with Catmap

Thomas Breslin, Patrik Edén, Morten Krogh BMC Bioinformatics 2004, 5:193 (9 December 2004)

Research article   Open Access

Handling multiple testing while interpreting microarrays with the Gene Ontology Database

Michael V Osier, Hongyu Zhao, Kei-Hoi Cheung BMC Bioinformatics 2004, 5:124 (6 September 2004)

Methodology article   Open Access Highly Accessed

Graph-based iterative Group Analysis enhances microarray interpretation

Rainer Breitling, Anna Amtmann, Pawel Herzyk BMC Bioinformatics 2004, 5:100 (23 July 2004)

Graph-based iterative Group Analysis (GiGA), a graph-based approach to identify biologically relevant changes in expression data, visually enhances microarray interpretation.

Research article   Open Access

Expression profile of genes regulated by activity of the Na-H exchanger NHE1

Luanna K Putney, Diane L Barber BMC Genomics 2004, 5:46 (16 July 2004)

Review   Free

Science review: Searching for gene candidates in acute lung injury

Dmitry N Grigoryev, James H Finigan, Paul Hassoun, Joe GN Garcia Critical Care 2004, 8:440-447 (30 June 2004)

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Visualization and analysis of microarray and gene ontology data with treemaps

Eric H Baehrecke, Niem Dang, Ketan Babaria, Ben Shneiderman BMC Bioinformatics 2004, 5:84 (28 June 2004)

Software   Open Access

B.E.A.R. GeneInfo: A tool for identifying gene-related biomedical publications through user modifiable queries

Guohui Zhou, Xinyu Wen, Hang Liu, Michael J Schlicht, Martin J Hessner, Peter J Tonellato, Milton W Datta BMC Bioinformatics 2004, 5:46 (29 April 2004)

Method   Open Access Highly Accessed

Orthologous gene-expression profiling in multi-species models: search for candidate genes

Dmitry N Grigoryev, Shwu-Fan Ma, Rafael A Irizarry, Shui Ye, John Quackenbush, Joe GN Garcia Genome Biology 2004, 5:R34 (27 April 2004)

An analytical approach that simultaneously evaluates multi-species experimental models is presented. This approach may be a useful tool in the selection of process-related candidate genes.

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Iterative Group Analysis (iGA): A simple tool to enhance sensitivity and facilitate interpretation of microarray experiments

Rainer Breitling, Anna Amtmann, Pawel Herzyk BMC Bioinformatics 2004, 5:34 (29 March 2004)

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GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies

Bing Zhang, Denise Schmoyer, Stefan Kirov, Jay Snoddy BMC Bioinformatics 2004, 5:16 (18 February 2004)

Research   Open Access Highly Accessed

Time- and exercise-dependent gene regulation in human skeletal muscle

Alexander C Zambon, Erin L McDearmon, Nathan Salomonis, Karen M Vranizan, Kirsten L Johansen, Deborah Adey, Joseph S Takahashi, Morris Schambelan, Bruce R Conklin Genome Biology 2003, 4:R61 (25 September 2003)

Skeletal muscle remodeling is a critical component of an organism's response to environmental changes. Exercise causes structural changes in muscle and can induce phase shifts in circadian rhythms, fluctuations in physiology and behavior with a period of around 24 hours that are maintained by a core clock mechanism. Both exercise-induced remodeling and circadian rhythms rely on the transcriptional regulation of key genes.

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Identifying biological themes within lists of genes with EASE

Douglas A Hosack, Glynn Dennis, Brad T Sherman, H Lane, Richard A Lempicki Genome Biology 2003, 4:R70 (11 September 2003)

EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data.