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MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

Scott W Doniger1, Nathan Salomonis1, Kam D Dahlquist12, Karen Vranizan14, Steven C Lawlor1 and Bruce R Conklin123*

Author affiliations

1 Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141-9100, USA

2 Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA

3 Departments of Medicine and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA

4 Functional Genomics Lab, University of California, Berkeley, CA 94720, USA

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Citation and License

Genome Biology 2003, 4:R7  doi:10.1186/gb-2003-4-1-r7

Published: 6 January 2003

Abstract

MAPPFinder is a tool that creates a global gene-expression profile across all areas of biology by integrating the annotations of the Gene Ontology (GO) Project with the free software package GenMAPP http://www.GenMAPP.org webcite. The results are displayed in a searchable browser, allowing the user to rapidly identify GO terms with over-represented numbers of gene-expression changes. Clicking on GO terms generates GenMAPP graphical files where gene relationships can be explored, annotated, and files can be freely exchanged.