Table 2

MAPPFinder results for genes significantly increased and significantly decreased in 12.5-day embryos versus adult mice
GO name
 Number changed
 Number measured
 Number in GO
 % Changed
 % Present
 z score
Significantly increased





     Process





          Mitotic cell cycle
 44
 70
 89
 62.9
 78.7
 8.1631
          DNA metabolism
 67
 135
 163
 49.6
 82.8
 7.6807
          mRNA splicing
 19
 21
 30
 90.5
 70
 7.4868
          RNA processing
 29
 41
 60
 70.7
 68.3
 7.4411
          RNA metabolism
 30
 44
 66
 68.2
 66.7
 7.3038
          Cell cycle
 98
 240
 291
 40.8
 82.5
 7.0096
          mRNA processing
 24
 33
 45
 72.7
 73.3
 6.9456
          Protein biosynthesis
 52
 104
 152
 50
 68.4
 6.8095
          Macromolecule biosynthesis
 57
 121
 172
 47.1
 70.3
 6.5863
          DNA replication
 28
 46
 55
 60.9
 83.6
 6.2752
          DNA replication and chromosome cycle
 29
 49
 62
 59.2
 79
 6.1944
          Ribosome biogenesis
 19
 28
 37
 67.9
 75.7
 5.7749
          Biosynthesis
 89
 242
 334
 36.8
 72.5
 5.4866
          DNA dependent DNA replication
 13
 18
 22
 72.2
 81.8
 5.0697
          Mitosis
 13
 18
 24
 72.2
 75
 5.0697
          Nuclear division
 14
 21
 30
 66.7
 70
 4.8663
          DNA packaging
 20
 36
 46
 55.6
 78.3
 4.7782
          Cell organization and biogenesis
 74
 207
 294
 35.7
 70.4
 4.6913
          M phase
 15
 25
 36
 60
 69.4
 4.5110
          mRNA splice site selection
 7
 8
 8
 87.5
 100
 4.4125
          DNA replication initiation
 6
 7
 7
 85.7
 100
 4.0138
          Chromosome organization and biogenesis (sensu Eukarya)
 18
 37
 51
 48.6
 72.5
 3.8338
          DNA repair
 21
 46
 53
 45.7
 86.8
 3.7895
          Protein folding
 12
 22
 31
 54.5
 71
 3.6157
          Cytoplasm organization and biogenesis
 56
 169
 241
 33.1
 70.1
 3.3912
          Establishment and/or maintenance of chromatin architecture
 13
 27
 35
 48.1
 77.1
 3.2089
          Protein synthesis elongation
 6
 9
 37
 66.7
 24.3
 3.1815
          Chromatin assembly/disassembly
 10
 20
 25
 50
 80
 2.9585
          Biological process unknown
 34
 98
 250
 34.7
 39.2
 2.9354
          Protein-ligand dependent protein degradation
 17
 43
 58
 39.5
 74.1
 2.6968
          Ubiquitin-dependent protein degradation
 16
 42
 57
 38.1
 73.7
 2.4404
          Protein-nucleus import
 5
 9
 10
 55.6
 90
 2.3820
          Ubiquitin cycle
 6
 12
 16
 50
 75
 2.2896
          Nucleocytoplasmic transport
 6
 12
 17
 50
 70.6
 2.2896
          Actin cytoskeleton organization and biogenesis
 6
 12
 19
 50
 63.2
 2.2896
          Transmembrane receptor protein Ser/Thr kinase signaling pathway
 10
 25
 31
 40
 80.6
 2.1081
          Induction of apoptosis
 7
 16
 24
 43.8
 66.7
 2.0449
     Component





          Spliceosome
 17
 20
 42
 85
 47.6
 6.7175
          Cytosolic ribosome (sensu Eukarya)
 19
 26
 33
 73.1
 78.8
 6.2032
          Cytosol
 40
 85
 112
 47.1
 75.9
 5.4872
          Ribosome
 35
 71
 93
 49.3
 76.3
 5.4624
          Chromosome
 19
 36
 55
 52.8
 65.5
 4.3772
          Nuclear envelope-endoplasmic reticulum network
 9
 12
 17
 75
 70.6
 4.3676
          Adherens junction
 6
 7
 14
 85.7
 50
 4.0138
          Endoplasmic reticulum membrane
 7
 9
 13
 77.8
 69.2
 3.9811
          Chromatin
 15
 28
 41
 53.6
 68.3
 3.9579
          Cellular component unknown
 41
 117
 291
 35
 40.2
 3.3057
          Nucleolus
 10
 19
 34
 52.6
 55.9
 3.1587
          26S proteasome
 11
 22
 23
 50
 95.7
 3.1036
          Endoplasmic reticulum
 39
 117
 141
 33.3
 83
 2.8569
          20S core proteasome
 9
 19
 19
 47.4
 100
 2.6078
          Nuclear membrane
 6
 11
 18
 54.5
 61.1
 2.5536
          Cytoskeleton
 64
 223
 306
 28.7
 72.9
 2.2918
          Collagen
 10
 25
 31
 40
 80.6
 2.1081
          Golgi membrane
 7
 16
 18
 43.8
 88.9
 2.0449
          Actin cytoskeleton
 16
 46
 63
 34.8
 73
 2.0140
     Function





          RNA binding
 51
 113
 155
 45.1
 72.9
 5.8498
          Cyclin-dependent protein kinase
 17
 24
 33
 70.8
 72.7
 5.6944
          Structural constituent of ribosome
 39
 83
 101
 47
 82.2
 5.4055
          Cyclin-dependent protein kinase, regulator
 12
 17
 24
 70.6
 70.8
 4.7646
          Structural molecule
 77
 223
 278
 34.5
 80.2
 4.4306
          Pre-mRNA splicing factor
 7
 8
 12
 87.5
 66.7
 4.4125
          mRNA binding
 10
 14
 19
 71.4
 73.7
 4.3979
          Protein serine/threonine kinase
 62
 181
 243
 34.3
 74.5
 3.8821
          Actin binding
 25
 58
 83
 43.1
 69.9
 3.7927
          Proteasome endopeptidase
 11
 19
 19
 57.9
 100
 3.7096
          DNA-directed DNA polymerase
 7
 10
 15
 70
 66.7
 3.6069
          RHO small monomeric GTPase
 7
 10
 10
 70
 100
 3.6069
          Nucleotidyltransferase
 16
 33
 41
 48.5
 80.5
 3.5964
          Kinase regulator
 15
 33
 42
 45.5
 78.6
 3.1777
          DNA dependent adenosinetriphosphatase
 8
 14
 16
 57.1
 87.5
 3.1151
          Cytoskeletal protein binding
 33
 93
 144
 35.5
 64.6
 3.0423
          DNA repair protein
 11
 23
 27
 47.8
 85.2
 2.9232
          Translation factor, nucleic acid binding
 14
 32
 43
 43.8
 74.4
 2.8970
          Transcription co-activator
 6
 10
 14
 60
 71.4
 2.8483
          Chromatin binding
 5
 8
 11
 62.5
 72.7
 2.7166
          Kinase
 89
 311
 394
 28.6
 78.9
 2.6983
          Phosphotransferase, alcohol group as acceptor
 87
 305
 386
 28.5
 79
 2.6301
          Protein kinase
 76
 263
 336
 28.9
 78.3
 2.5796
          Exonuclease
 6
 11
 15
 54.5
 73.3
 2.5536
          Small monomeric GTPase
 15
 38
 46
 39.5
 82.6
 2.5247
          GTP binding
 43
 141
 201
 30.5
 70.1
 2.3248
          Peptidylprolyl cis-trans isomerase
 6
 12
 16
 50
 75
 2.2896
          Translation elongation factor
 6
 12
 16
 50
 75
 2.2896
          Transcription factor binding
 11
 27
 43
 40.7
 62.8
 2.2838
          Guanyl nucleotide binding
 46
 155
 219
 29.7
 70.8
 2.1927
          Adenosinetriphosphatase
 12
 31
 38
 38.7
 81.6
 2.1763
          Molecular_function unknown
 29
 91
 230
 31.9
 39.6
 2.1739
          Protein binding
 99
 368
 539
 26.9
 68.3
 2.1328
          Chaperone
 16
 45
 62
 35.6
 72.6
 2.1166
          Extracellular matrix structural constituent conferring tensile strength
 10
 25
 31
 40
 80.6
 2.1081
          DNA-directed RNA polymerase
 5
 10
 11
 50
 90.9
 2.0897
          Structural constituent of cytoskeleton
 21
 63
 79
 33.3
 79.7
 2.0838
          Transferase, transferring one-carbon groups
 8
 19
 29
 42.1
 65.5
 2.0570
          GTPase
 25
 78
 95
 32.1
 82.1
 2.0488
          Isomerase
 12
 32
 42
 37.5
 76.2
 2.0468
Significantly decreased





     Process





          Fatty acid metabolism
 19
 30
 41
 63.3
 73.2
 5.9082
          Main pathways of carbohydrate metabolism
 20
 39
 50
 51.3
 78
 4.8600
          Energy derivation by oxidation of organic compounds
 23
 50
 66
 46
 75.8
 4.5739
          Catabolic carbohydrate metabolism
 18
 36
 45
 50
 80
 4.4754
          Tricarboxylic acid cycle
 6
 8
 10
 75
 80
 3.8664
          Hexose metabolism
 18
 41
 49
 43.9
 83.7
 3.8016
          Lipid metabolism
 42
 127
 167
 33.1
 76
 3.6708
          Lipid transport
 5
 7
 11
 71.4
 63.6
 3.3807
          Glycolysis
 12
 26
 32
 46.2
 81.2
 3.3091
          Peroxisome organization and biogenesis
 7
 12
 15
 58.3
 80
 3.2972
          Glucose metabolism
 15
 36
 42
 41.7
 85.7
 3.2247
          Lymph gland development
 8
 15
 17
 53.3
 88.2
 3.2043
          Cell proliferation
 10
 21
 34
 47.6
 61.8
 3.1400
          Humoral immune response
 15
 37
 79
 40.5
 46.8
 3.0982
          Carbohydrate metabolism
 31
 95
 135
 32.6
 70.4
 3.0557
          Regulation of cell proliferation
 5
 8
 15
 62.5
 53.3
 2.9848
          Muscle contraction
 9
 20
 28
 45
 71.4
 2.7716
          Muscle development
 13
 34
 43
 38.2
 79.1
 2.6328
          Mesoderm development
 28
 90
 111
 31.1
 81.1
 2.6096
          Potassium transport
 17
 49
 60
 34.7
 81.7
 2.5450
          Metal ion transport
 24
 77
 100
 31.2
 77
 2.4230
          Monovalent inorganic cation transport
 21
 67
 88
 31.3
 76.1
 2.2935
          Complement activation
 8
 20
 23
 40
 87
 2.2132
          Cation transport
 28
 98
 135
 28.6
 72.6
 2.0923
          Electron transport
 25
 87
 113
 28.7
 77
 2.0075
     Component





          Mitochondrion
 88
 187
 293
 47.1
 63.8
 9.3508
          Peroxisome
 18
 29
 42
 62.1
 69
 5.6381
          Mitochondrial inner membrane
 19
 36
 60
 52.8
 60
 4.8922
          Mitochondrial electron transport chain complex
 10
 14
 32
 71.4
 43.8
 4.7848
          Mitochondrial membrane
 20
 40
 72
 50
 55.6
 4.7195
          Cytochrome C oxidase
 6
 8
 16
 75
 50
 3.8664
          Mitochondrial matrix
 9
 22
 33
 40.9
 66.7
 2.4283
          Basement lamina
 5
 11
 11
 45.5
 100
 2.0910
          Cytoskeleton
 57
 223
 306
 25.6
 72.9
 2.0527
     Function





          Hydrogen ion transporter
 11
 15
 33
 73.3
 45.5
 5.1373
          Primary active transporter
 27
 64
 107
 42.2
 59.8
 4.4175
          Cation transporter
 17
 36
 61
 47.2
 59
 4.0585
          Ion transporter
 19
 43
 79
 44.2
 54.4
 3.9406
          Cytochrome c oxidase
 6
 8
 16
 75
 50
 3.8664
          Oxidoreductase
 48
 149
 207
 32.2
 72
 3.7213
          Major histocompatibility complex antigen
 13
 30
 54
 43.3
 55.6
 3.1700
          Oxidoreductase, acting on the aldehyde or oxo group of donors
 7
 13
 16
 53.8
 81.2
 3.0285
          Carrier
 40
 131
 196
 30.5
 66.8
 2.9960
          Complement component
 8
 16
 19
 50
 84.2
 2.9770
          P-type ATPase
 5
 9
 11
 55.6
 81.8
 2.6467
          Hydrolase, acting on acid anhydrides, catalyzing transmembrane movement of substances
 15
 42
 67
 35.7
 62.7
 2.5199
          Nucleobase, nucleoside, nucleotide kinase
 7
 16
 19
 43.8
 84.2
 2.3531
          Phosphotransferase, phosphate group as acceptor
 5
 10
 13
 50
 76.9
 2.3520
          Glutathione transferase
 5
 10
 13
 50
 76.9
 2.3520
          P-P-bond-hydrolysis-driven transporter
 17
 52
 78
 32.7
 66.7
 2.2609
          ATP-binding cassette (ABC) transporter
 11
 30
 50
 36.7
 60
 2.2573
          Potassium channel
 15
 45
 56
 33.3
 80.4
 2.2093
          Carbon-carbon lyase
 5
 11
 18
 45.5
 61.1
 2.0910

All terms with a z score of 2 and at least 5, but less than 100 genes meeting the criterion are shown.

Doniger et al. Genome Biology 2003 4:R7   doi:10.1186/gb-2003-4-1-r7

Open Data